Details:

Alternative Title:
Sci Transl Med
Personal Author:
Ifft, Peter J. ; Shokur, Solaiman ; Li, Zheng ; Lebedev, Mikhail A. ; Nicolelis, Miguel A. L.
Ifft, Peter J. ; Shokur, Solaiman ; Li, Zheng ; Lebedev, Mikhail A. ; Nicolelis, Miguel A. L. Less -
Description:
Brain-machine interfaces (BMIs) are artificial systems that aim to restore sensation and movement to paralyzed patients. So far, BMIs have enabled only one arm to be moved at a time. Control of bimanual arm movements remains a major challenge. We have developed and tested a bimanual BMI that enables rhesus monkeys to control two avatar arms simultaneously. The bimanual BMI was based on the extracellular activity of 374 to 497 neurons recorded from several frontal and parietal cortical areas of both cerebral hemispheres. Cortical activity was transformed into movements of the two arms with a decoding algorithm called a fifth-order unscented Kalman filter (UKF). The UKF was trained either during a manual task performed with two joysticks or by having the monkeys passively observe the movements of avatar arms. Most cortical neurons changed their modulation patterns when both arms were engaged simultaneously. Representing the two arms jointly in a single UKF decoder resulted in improved decoding performance compared with using separate decoders for each arm. As the animals' performance in bimanual BMI control improved over time, we observed widespread plasticity in frontal and parietal cortical areas. Neuronal representation of the avatar and reach targets was enhanced with learning, whereas pairwise correlations between neurons initially increased and then decreased. These results suggest that cortical networks may assimilate the two avatar arms through BMI control. These findings should help in the design of more sophisticated BMIs capable of enabling bimanual motor control in human patients.
Subject:
[+]
Algorithms
Animals
Arm
Article
Behavior, Animal
Brain-Computer Interfaces
Cerebral Cortex
Electrodes, Implanted
Female
Haplorhini
Humans
Male
Movement
Neuronal Plasticity
Neurons
Task Performance And Analysis

Source:
Sci Transl Med. 5(210):210ra154
Pubmed ID:
24197735
Pubmed Central ID:
PMC3967722
Document Type:
Journal Article
Funding:
F31 NS081931/NS/NINDS NIH HHS/United States ; DP1MH099903/DP/NCCDPHP CDC HHS/United States ; R01NS073952/NS/NINDS NIH HHS/United States ; DP1 MH099903/MH/NIMH NIH HHS/United States ; R01 NS073952/NS/NINDS NIH HHS/United States
F31 NS081931/NS/NINDS NIH HHS/United States ; DP1MH099903/DP/NCCDPHP CDC HHS/United States ; R01NS073952/NS/NINDS NIH HHS/United States ; DP1 MH099903/MH/NIMH NIH HHS/United States ; R01 NS073952/NS/NINDS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5d2e2c54d7b165b3bf8b9ea76e0ab5f82cf61be580245436f3c7b8605b177a46
File Type:

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