Details:

Alternative Title:
IEEE Trans Biomed Eng
Publisher's site:
http://dx.doi.org/10.1109/TBME.2013.2283507
Personal Author:
Xia, Jun ; Wang, Lihong V.
Xia, Jun ; Wang, Lihong V. Less -
Description:
With the wide use of small animals for biomedical studies, in vivo small-animal whole-body imaging plays an increasingly important role. Photoacoustic tomography (PAT) is an emerging whole-body imaging modality that shows great potential for preclinical research. As a hybrid technique, PAT is based on the acoustic detection of optical absorption from either endogenous tissue chromophores, such as oxyhemoglobin and deoxyhemoglobin, or exogenous contrast agents. Because ultrasound scatters much less than light in tissue, PAT generates high-resolution images in both the optical ballistic and diffusive regimes. Using near-infrared light, which has relatively low blood absorption, PAT can image through the whole body of small animals with acoustically defined spatial resolution. Anatomical and vascular structures are imaged with endogenous hemoglobin contrast, while functional and molecular images are enabled by the wide choice of exogenous optical contrasts. This paper reviews the rapidly growing field of small-animal whole-body PAT and highlights studies done in the past decade.
Subject:
[+]
Anatomical Imaging
Animals
Article
Computed Tomography
Female
Fluorescent Protein
Functional Imaging
Kidney Perfusion
Male
Metabolic Imaging
Mice
Molecular Imaging
Nanoparticle Distribution
Perfusion Imaging
Photoacoustic Macroscopy
Photoacoustic Techniques
Photoacoustic Tomography
Rats
Small Animal Whole Body Imaging
Tomography, X-Ray Computed
Whole Body Imaging

Source:
IEEE Trans Biomed Eng. 2013; 61(5):1380-1389.
Pubmed ID:
24108456
Pubmed Central ID:
PMC3965654
Document Type:
Journal Article
Funding:
DP1 EB016986/DP/NCCDPHP CDC HHS/United States ; DP1 EB016986/EB/NIBIB NIH HHS/United States ; R01 CA134539/CA/NCI NIH HHS/United States ; R01 CA157277/CA/NCI NIH HHS/United States ; R01 CA159959/CA/NCI NIH HHS/United States ; ... More +
DP1 EB016986/DP/NCCDPHP CDC HHS/United States ; DP1 EB016986/EB/NIBIB NIH HHS/United States ; R01 CA134539/CA/NCI NIH HHS/United States ; R01 CA157277/CA/NCI NIH HHS/United States ; R01 CA159959/CA/NCI NIH HHS/United States ; R01 EB008085/EB/NIBIB NIH HHS/United States ; R01 EB008085/EB/NIBIB NIH HHS/United States ; R01 EB010049/EB/NIBIB NIH HHS/United States ; R01 EB010049/EB/NIBIB NIH HHS/United States ; R01 EB016963/EB/NIBIB NIH HHS/United States ; R01 EB016963/EB/NIBIB NIH HHS/United States ; R01CA134539/CA/NCI NIH HHS/United States ; R01CA157277/CA/NCI NIH HHS/United States ; R01CA159959/CA/NCI NIH HHS/United States ; U54 CA136398/CA/NCI NIH HHS/United States ; U54CA136398/CA/NCI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:403b0c810cc1c2e48314b4b8a45ff104605e74a386b18ab58e13e9e36136ae0d
File Type:

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