Details:

Alternative Title:
Org Lett
Publisher's site:
http://dx.doi.org/10.1021/ol403714g
Personal Author:
Waldman, Abraham J. ; Balskus*, Emily P.
Waldman, Abraham J. ; Balskus*, Emily P. Less -
Description:
Lomaiviticin biosynthesis is thought to utilize a propionyl starter unit for a type II polyketide synthase (PKS). Discovery of the lomaiviticin (lom) biosynthetic gene cluster suggested an unusual method for starter unit generation involving a bifunctional acyltransferase/decarboxylase (AT/DC) thus far observed only in type I PKS pathways. In vitro biochemical characterization of AT/DC Lom62 confirmed its ability to generate a propionyl-acyl carrier protein (ACP), revealing a new role for this enzymatic activity within natural product biosynthesis.
Subject:
[+]
Acyl Carrier Protein
Acyltransferases
Amino Acid Sequence
Article
Fluorenes
Molecular Structure
Multigene Family
Polyketide Synthases
Streptomyces

Source:
Org Lett. 16(2):640-643.
Pubmed ID:
24383813
Pubmed Central ID:
PMC3965344
Document Type:
Journal Article
Funding:
DP2 GM105434/DP/NCCDPHP CDC HHS/United States ; DP2 GM105434/GM/NIGMS NIH HHS/United States ; GM095450/GM/NIGMS NIH HHS/United States ; T32 GM095450/GM/NIGMS NIH HHS/United States
DP2 GM105434/DP/NCCDPHP CDC HHS/United States ; DP2 GM105434/GM/NIGMS NIH HHS/United States ; GM095450/GM/NIGMS NIH HHS/United States ; T32 GM095450/GM/NIGMS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f2505bccc95bc1830afe40aaf3563067e72e86786eb8f2a664bb00e7d19ee2d6
File Type:

Supporting Files

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