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Lomaiviticin Biosynthesis Employs a New Strategy for Starter Unit Generation
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1 17 2014
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Source: Org Lett. 16(2):640-643
Details:
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Alternative Title:Org Lett
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Personal Author:
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Description:Lomaiviticin biosynthesis is thought to utilize a propionyl starter unit for a type II polyketide synthase (PKS). Discovery of the lomaiviticin (lom) biosynthetic gene cluster suggested an unusual method for starter unit generation involving a bifunctional acyltransferase/decarboxylase (AT/DC) thus far observed only in type I PKS pathways. In vitro biochemical characterization of AT/DC Lom62 confirmed its ability to generate a propionyl-acyl carrier protein (ACP), revealing a new role for this enzymatic activity within natural product biosynthesis.
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Pubmed ID:24383813
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Pubmed Central ID:PMC3965344
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Volume:16
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Issue:2
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[PDF-642.01 KB]
