ONE AIRWAY: BIOMARKERS OF PROTECTION FROM UPPER AND LOWER AIRWAY INJURY AFTER WORLD TRADE CENTER EXPOSURE

Details

• Alternative Title:
  Respir Med
• Personal Author:
  Cho, Soo Jung ; Echevarria, Ghislaine C. ; Kwon, Sophia ; Naveed, Bushra ; Schenck, Edward J ; Tsukiji, Jun ; Rom, William N. ; Prezant, David J. ; Nolan, Anna ; Weiden, Michael D.
• Description:
  Background
  
  Firefighters exposed to World Trade Center (WTC) dust have developed chronic rhinosinusitis (CRS) and abnormal forced expiratory volume in 1 second (FEV1). Overlapping but distinct immune responses may be responsible for the clinical manifestations of upper and lower airway injury. We investigated whether a panel of inflammatory cytokines, either associated or not associated with WTC-LI, can predict future chronic rhinosinusitis disease and its severity.
  
  Methods
  
  Serum obtained within six months of 9/11/2001 from 179 WTC exposed firefighters presenting for subspecialty evaluation prior to 3/2008 was assayed for 39 cytokines. The main outcomes were medically managed CRS (N=62) and more severe CRS cases requiring sinus surgery (N=14). We tested biomarker-CRS severity association using ordinal logistic regression analysis.
  
  Results
  
  Increasing serum IL-6, IL-8, GRO and neutrophil concentration reduced the risk of CRS progression. Conversely, increasing TNF-α increased the risk of progression. In a multivariable model adjusted for exposure intensity, increasing IL-6, TNF-α and neutrophil concentration remained significant predictors of progression. Elevated IL-6 levels and neutrophil counts also reduced the risk of abnormal FEV1 but in contrast to CRS, increased TNF-α did not increase the risk of abnormal FEV1.
  
  Conclusions
  
  Our study demonstrates both independent and overlapping biomarker associations with upper and lower respiratory injury, and suggests that the innate immune response may play a protective role against CRS and abnormal lung function in those with WTC exposure.
  
  
• Subjects:
  Article Biomarkers Chronic Rhinosinusitis Dust Firefighters Forced Expiratory Volume Humans Inflammation Innate Immunity Interleukin-6 Interleukin-8 Lung Injury Male Neutrophils New York Occupational Exposure One Airway Respiratory Tract Diseases Rhinitis Risk Assessment Risk Factors September 11 Terrorist Attacks Severity Of Illness Index Sinusitis Tumor Necrosis Factor-alpha World Trade Center

  More +
• Source:
  Respir Med. 2013; 108(1):162-170.
• Pubmed ID:
  24290899
• Pubmed Central ID:
  PMC3946892
• Document Type:
  Journal Article
• Funding:
  1 UL1RR029893/RR/NCRR NIH HHS/United States ; AL080298A/PHS HHS/United States ; HL090316/HL/NHLBI NIH HHS/United States ; K23HL084191/HL/NHLBI NIH HHS/United States ; K24 AI080298/AI/NIAID NIH HHS/United States ; K24A1080298/PHS HHS/United States ; R01HL057879/HL/NHLBI NIH HHS/United States ; R01HL090316/HL/NHLBI NIH HHS/United States ; T32 ES007267/ES/NIEHS NIH HHS/United States ; TL1RR029892/RR/NCRR NIH HHS/United States ; U01CA008617/CA/NCI NIH HHS/United States ; U10- OH008243/OH/NIOSH CDC HHS/United States ; U10-OH008242/OH/NIOSH CDC HHS/United States ; UL1TR000038/TR/NCATS NIH HHS/United States
• Volume:
  108
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:9a6f4ce307d245aa8ab07060eaaeebcf2d2416e65e2f35b25e3444f67bc477d7
• Download URL:
  https://stacks.cdc.gov/view/cdc/29874/cdc_29874_DS1.pdf
• File Type:
  [PDF - 540.30 KB ]