One airway: biomarkers of protection from upper and lower airway injury after World Trade Center exposure

Details

• Personal Author:
  Cho SJ ; Echevarria GC ; Kwon S ; Naveed B ; Nolan A ; Prezant DJ ; Rom, William N. ; Schenck EJ ; Tsukiji J ; Weiden MD
• Description:
  BACKGROUND: Firefighters exposed to World Trade Center (WTC) dust have developed chronic rhinosinusitis (CRS) and abnormal forced expiratory volume in 1 s (FEV1). Overlapping but distinct immune responses may be responsible for the clinical manifestations of upper and lower airway injury. We investigated whether a panel of inflammatory cytokines, either associated or not associated with WTC-LI, can predict future chronic rhinosinusitis disease and its severity. METHODS: Serum obtained within six months of 9/11/2001 from 179 WTC exposed firefighters presenting for subspecialty evaluation prior to 3/2008 was assayed for 39 cytokines. The main outcomes were medically managed CRS (N = 62) and more severe CRS cases requiring sinus surgery (N = 14). We tested biomarker-CRS severity association using ordinal logistic regression analysis. RESULTS: Increasing serum IL-6, IL-8, GRO and neutrophil concentration reduced the risk of CRS progression. Conversely, increasing TNF-alpha increased the risk of progression. In a multivariable model adjusted for exposure intensity, increasing IL-6, TNF-a and neutrophil concentration remained significant predictors of progression. Elevated IL-6 levels and neutrophil counts also reduced the risk of abnormal FEV1 but in contrast to CRS, increased TNF-alpha did not increase the risk of abnormal FEV1. CONCLUSIONS: Our study demonstrates both independent and overlapping biomarker associations with upper and lower respiratory injury, and suggests that the innate immune response may play a protective role against CRS and abnormal lung function in those with WTC exposure. [Description provided by NIOSH]
• Subjects:
  Chronic Disease Cytotoxins Dust Emergency Responders Firefighters Immune System Lung Diseases Nose Occupational Exposure Occupational Health Particulate Matter Respiratory Tract Diseases Safety Sense Organs September 11 Terrorist Attacks

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• Keywords:
  Airway-obstruction Author Keywords: One Airway Chronic-inflammation Chronic Rhinosinusitis Cytotoxicity Dust-exposure Emergency-responders Employee-exposure Fire-fighters Immune-reaction Innate Immunity Lung-disorders Nasal-disorders Particulate-dust Pulmonary-system-disorders Respiratory-system-disorders World Trade Center

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• ISSN:
  0954-6111
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  162-170
• Volume:
  108
• Issue:
  1
• NIOSHTIC Number:
  nn:20044400
• Citation:
  Respir Med 2014 Jan; 108(1):162-170
• Contact Point Address:
  Michael D. Weiden, New York University School of Medicine, 550 1st Ave, New York, NY 10016, USA
• Email:
  michael.weiden@med.nyu.edu
• Federal Fiscal Year:
  2014
• Performing Organization:
  New York City Fire Department
• Peer Reviewed:
  True
• Start Date:
  20040701
• Source Full Name:
  Respiratory Medicine
• End Date:
  20110630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f9ae638e2f817b207938011fbd0e96ec65cb558a1c349333fd12af6514b49261fc260aaa95d91b7bfee88f28188ce605663b1cfd6e78426986b3de2d6caf27c9
• Download URL:
  https://stacks.cdc.gov/view/cdc/200108/cdc_200108_DS1.pdf
• File Type:
  [PDF - 373.67 KB ]