Seasonal Variation of 25-Hydroxyvitamin-D among non-Hispanic Black and White Pregnant Women from Three U.S. Pregnancy Cohorts

Details

• Alternative Title:
  Paediatr Perinat Epidemiol
• Personal Author:
  Luque-Fernandez, Miguel Angel ; Gelaye, Bizu ; Vander Weele, Tyler ; Ferre, Cynthia ; Siega-Riz, Anna Maria ; Holzman, Claudia ; Enquobahrie, Daniel A. ; Dole, Nancy ; Williams, Michelle A.
• Description:
  Background
  
  Vitamin D deficiency during pregnancy has been associated with increased risk of complications and adverse perinatal outcomes. We evaluated seasonal variation of 25(OH)D among pregnant women, focusing on patterns and determinants of variation.
  
  Methods
  
  Data came from three cohort studies in the US that included 2,583 non-Hispanic Black and White women having prenatal 25(OH)D concentrations determined. Fourier time series and generalised linear models were used to estimate the magnitude of 25(OH)D seasonality. We modelled seasonal variability using a stationary cosinor model to estimate the phase shift, peak-trough difference, and annual mean of 25(OH)D.
  
  Results
  
  We observed a peak for 25(OH)D in summer, a nadir in winter, and a phase of 8 months, which resulted from fluctuations in 25(OH)D3 rather than 25(OH)D2. After adjustment for covariates, the annual mean concentrations and estimated peak–trough difference of 25(OH)D among Black women were 19.8 ng/mL (95% CI 18.9, 20.5), and 5.8 ng/mL (95% CI 4.7, 6.7), and for non-Hispanic White women, 33.0 ng/mL (95% CI 32.6, 33.4) and 7.4 ng/mL (95% CI 6.0, 8.9).
  
  Conclusions
  
  Non-Hispanic Black women had lower average 25(OH)D concentrations throughout the year and smaller seasonal variation levels than non-Hispanic White women. This study's confirmation of 25(OH)D seasonality over a calendar year, has the potential to enhance public health interventions targeted to improve maternal and perinatal outcomes.
  
  
• Subjects:
  Adult Black Or African American Cohort Studies Dietary Supplements Female Humans Maternal Nutritional Physiological Phenomena Pregnancy Pregnant Women Prevalence Risk Factors Seasons Sunlight Vitamin D Vitamin D Deficiency White People

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• Source:
  Paediatr Perinat Epidemiol. 28(2):166-176
• Pubmed ID:
  24354847
• Pubmed Central ID:
  PMC3946392
• Document Type:
  Journal Article
• Funding:
  R01 HD-34543/HD/NICHD NIH HHS/United States ; U01 DP000143-01/DP/NCCDPHP CDC HHS/United States ; R01 HD034543/HD/NICHD NIH HHS/United States ; CC999999/Intramural CDC HHS/United States ; R01 HD-034543/HD/NICHD NIH HHS/United States ; U01 DP000143/DP/NCCDPHP CDC HHS/United States ; R01 HD032562/HD/NICHD NIH HHS/United States ; R24 HD050924/HD/NICHD NIH HHS/United States ; R01-HD-32562/HD/NICHD NIH HHS/United States
• Place as Subject:
  United States
• Volume:
  28
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d22c0f1f4233b4d7e0ae5027cdead2bd33f2609825bfb739d8db3a355f520c86
• Download URL:
  https://stacks.cdc.gov/view/cdc/29870/cdc_29870_DS1.pdf
• File Type:
  [PDF - 1.26 MB ]