CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Systems genetics approaches to understand complex traits
-
1 2014
-
Source: Nat Rev Genet. 2014; 15(1):34-48
Details:
-
Alternative Title:Nat Rev Genet
-
Personal Author:
-
Description:Systems genetics is an approach to understand the flow of biological information that underlies complex traits. It uses a range of experimental and statistical methods to quantitate and integrate intermediate phenotypes, such as transcript, protein or metabolite levels, in populations that vary for traits of interest. Systems genetics studies have provided the first global view of the molecular architecture of complex traits and are useful for the identification of genes, pathways and networks that underlie common human diseases. Given the urgent need to understand how the thousands of loci that have been identified in genome-wide association studies contribute to disease susceptibility, systems genetics is likely to become an increasingly important approach to understanding both biology and disease.
-
Keywords:
-
Source:
-
Pubmed ID:24296534
-
Pubmed Central ID:PMC3934510
-
Document Type:
-
Funding:
-
Volume:15
-
Issue:1
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type: