Systems genetics approaches to understand complex traits
Published Date:Dec 03 2013
Source:Nat Rev Genet. 2014; 15(1):34-48.
Pubmed Central ID:PMC3934510
Funding:DP3D094311/DP/NCCDPHP CDC HHS/United States
HL094322/HL/NHLBI NIH HHS/United States
HL110667/HL/NHLBI NIH HHS/United States
HL28481/HL/NHLBI NIH HHS/United States
HL30568/HL/NHLBI NIH HHS/United States
P01 HL028481/HL/NHLBI NIH HHS/United States
R01 HL123295/HL/NHLBI NIH HHS/United States
T32 HL069766/HL/NHLBI NIH HHS/United States
T32HL69766/HL/NHLBI NIH HHS/United States
Description:Systems genetics is an approach to understand the flow of biological information that underlies complex traits. It uses a range of experimental and statistical methods to quantitate and integrate intermediate phenotypes, such as transcript, protein or metabolite levels, in populations that vary for traits of interest. Systems genetics studies have provided the first global view of the molecular architecture of complex traits and are useful for the identification of genes, pathways and networks that underlie common human diseases. Given the urgent need to understand how the thousands of loci that have been identified in genome-wide association studies contribute to disease susceptibility, systems genetics is likely to become an increasingly important approach to understanding both biology and disease.
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