Details:

Alternative Title:
Nat Rev Genet
Personal Author:
Civelek, Mete ; Lusis, Aldons J.
Civelek, Mete ; Lusis, Aldons J. Less -
Description:
Systems genetics is an approach to understand the flow of biological information that underlies complex traits. It uses a range of experimental and statistical methods to quantitate and integrate intermediate phenotypes, such as transcript, protein or metabolite levels, in populations that vary for traits of interest. Systems genetics studies have provided the first global view of the molecular architecture of complex traits and are useful for the identification of genes, pathways and networks that underlie common human diseases. Given the urgent need to understand how the thousands of loci that have been identified in genome-wide association studies contribute to disease susceptibility, systems genetics is likely to become an increasingly important approach to understanding both biology and disease.
Subjects:
[+]
Animals Article Epistasis, Genetic Gene Expression Regulation Gene Regulatory Networks Genetic Loci Genetic Predisposition To Disease Genetic Techniques Genome-Wide Association Study Humans Models, Genetic Phenotype Systems Biology
Source:
Nat Rev Genet. 2014; 15(1):34-48.
Pubmed ID:
24296534
Pubmed Central ID:
PMC3934510
Document Type:
Journal Article
Funding:
DP3D094311/DP/NCCDPHP CDC HHS/United States ; HL094322/HL/NHLBI NIH HHS/United States ; HL110667/HL/NHLBI NIH HHS/United States ; HL28481/HL/NHLBI NIH HHS/United States ; HL30568/HL/NHLBI NIH HHS/United States ; ... More +
DP3D094311/DP/NCCDPHP CDC HHS/United States ; HL094322/HL/NHLBI NIH HHS/United States ; HL110667/HL/NHLBI NIH HHS/United States ; HL28481/HL/NHLBI NIH HHS/United States ; HL30568/HL/NHLBI NIH HHS/United States ; P01 HL028481/HL/NHLBI NIH HHS/United States ; R01 HL123295/HL/NHLBI NIH HHS/United States ; T32 HL069766/HL/NHLBI NIH HHS/United States ; T32HL69766/HL/NHLBI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:3b58227547c119be808a4e8e41a67dc9533cb96f60aa9adc847d03364c1677fb
Download URL:
https://stacks.cdc.gov/view/cdc/29860/cdc_29860_DS1.pdf
File Type:

Supporting Files

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