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Genetic ancestry and risk of mortality among U.S. Latinas with breast cancer
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    Multiple studies have reported that Latina women in the United States are diagnosed with breast cancer at more advanced stages and have poorer survival than non-Latina White women. However, Latinas are a heterogeneous group with individuals having different proportions of European, Indigenous American, and African genetic ancestry. In this study, we evaluated the association between genetic ancestry and survival after breast cancer diagnosis among 899 Latina women from the San Francisco Bay area. Genetic ancestry was estimated from single-nucleotide polymorphisms from an Affymetrix 6.0 array and we used Cox proportional hazards models to evaluate the association between genetic ancestry and breast cancer-specific mortality (tests were two-sided). Women were followed for an average of 9 years during which 75 died from breast cancer. Our results showed that Individuals with higher Indigenous American ancestry had increased risk of breast cancer-specific mortality [HR: 1.57 per 25% increase in Indigenous American ancestry; 95% confidence interval (CI): 1.08-2.29]. Adjustment for demographic factors, tumor characteristics, and some treatment information did not explain the observed association (HR: 1.75; 95%CI, 1.12-2.74). In an analysis in which ancestry was dichotomized, the hazard of mortality showed a two-fold increase when comparing women with less than 50% Indigenous American ancestry to women with 50% or more [HR, 1.89, 95%CI, 1.10-3.24]. This was also reflected by Kaplan-Meier survival estimates (P for log-rank test of 0.003). Overall, results suggest that genetic factors and/or unmeasured differences in treatment or access to care should be further explored to understand and reduce ethnic disparities in breast cancer outcomes.

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    1U54CA153511/CA/NCI NIH HHS/United States
    CA 160607/CA/NCI NIH HHS/United States
    CA120120/CA/NCI NIH HHS/United States
    CA63446/CA/NCI NIH HHS/United States
    CA77305/CA/NCI NIH HHS/United States
    HHSN261201000034C/PHS HHS/United States
    HHSN261201000140C/PHS HHS/United States
    K01 CA160607/CA/NCI NIH HHS/United States
    K24 CA169004/CA/NCI NIH HHS/United States
    P30 AG015272/AG/NIA NIH HHS/United States
    P30-AG15272/AG/NIA NIH HHS/United States
    R01 CA120120/CA/NCI NIH HHS/United States
    U58DP003862-01/DP/NCCDPHP CDC HHS/United States
    UM1 CA164920/CA/NCI NIH HHS/United States
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