Angiotensin receptor blockers: are they related to lung cancer?

Details

• Alternative Title:
  J Hypertens
• Personal Author:
  Rao, Gowtham Adamane ; Mann, Joshua R. ; Shoaibi, Azza ; Pai, Sachin G. ; Bottai, Matteo ; Sutton, Shawn Scott ; Haddock, Kathlyn Sue ; Bennett, Charles Lee ; Hebert, James R.
• Description:
  Introduction
  
  Angiotensin receptor blockers (ARBs) are commonly used antihypertensive medication with several other additional proven benefits. Recent controversy on association of lung cancer and other solid malignancy with the use of ARBs is concerning, although the follow-up studies have shown no such association.
  
  Methods
  
  We used data from the Department of Veterans Affairs electronic medical record system and registries to conduct a retrospective cohort study that compared first-time ARB users with nonusers in 1:15 ratio, after balancing for many baseline differences using inverse probability of treatment weights. We conducted time-to-event survival analyses on the weighted cohort.
  
  Results
  
  Of the 1 229 902 patients in the analytic cohort, 346 (0.44%) of the 78 075 treated individuals had a newly incident lung cancer and 6577 (0.57%) of 1 151 826 nontreated individuals were diagnosed with lung cancer. On double robust regression, the weighted hazard ratio was 0.74 (0.67–0.83, P<0.0001), suggesting a lung cancer reduction effect with ARB use. There was no difference in rates by ARB subtype.
  
  Conclusion
  
  In this large nationwide cohort of United States Veterans, we found no evidence to support any concern of increased risk of lung cancer among new users of ARBs compared with nonusers. Our findings were consistent with a protective effect of ARBs.
  
  
• Subjects:
  Adult Aged Angiotensin Receptor Antagonists Antihypertensive Agents Cohort Studies Electronic Health Records Female Humans Hypertension Lung Neoplasms Male Middle Aged Proportional Hazards Models Regression Analysis Retrospective Studies Time Factors

  More +
• Source:
  J Hypertens. 2013; 31(8):1669-1675.
• Pubmed ID:
  23822929
• Pubmed Central ID:
  PMC3879726
• Document Type:
  Journal Article
• Funding:
  K05 CA136975/CA/NCI NIH HHS/United States ; U48 DP001936/DP/NCCDPHP CDC HHS/United States ; U54 CA153461/CA/NCI NIH HHS/United States ; U54CA153461/CA/NCI NIH HHS/United States
• Name as Subject:
  United States. Department of Veterans Affairs.
• Place as Subject:
  United States
• Volume:
  31
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8063930112778504190978dc804d376c7f0354954544acf6238367c4d09fe01d
• Download URL:
  https://stacks.cdc.gov/view/cdc/29816/cdc_29816_DS1.pdf
• File Type:
  [PDF - 909.19 KB ]