Longitudinal design for sonographic measurement of median nerve swelling with controlled exposure to physical work using an animal model

Roll, Shawn C.; Evans, Kevin D.; Volz, Kevin R.; Sommerich, Carolyn M.

doi:10.1016/j.ultrasmedbio.2013.08.008

i

Longitudinal design for sonographic measurement of median nerve swelling with controlled exposure to physical work using an animal model

Supporting Files

Oct 16 2013
By Roll, Shawn C. ; Evans, Kevin D. ; Volz, Kevin R. ; ...

File Language:

English

Details

Alternative Title:

Ultrasound Med Biol
Personal Author:

Roll, Shawn C. ; Evans, Kevin D. ; Volz, Kevin R. ; Sommerich, Carolyn M.
Description:

In the study described here, we examined the feasibility of a longitudinal design to measure sonographically swelling of the median nerve caused by controlled exposure to a work task and to evaluate the relationship of changes in morphology to diagnostic standards. Fifteen macaques, Macaca fascicularis, pinched a lever in various wrist positions at a self-regulated pace (8 h/d, 5 d/wk, 18-20 wk). Nerve conduction velocity (NCV) and cross-sectional area (CSA) were measured every 2 wk from baseline through working and a 6-wk recovery. Trending across all subjects revealed that NCV slowed and CSA at the carpal tunnel increased in the working arm, whereas no changes were observed in CSA either at the forearm or for any measure in the non-working arm. There was a small negative correlation between NCV and CSA in the working arm. This study provides validation that swelling can be observed using a longitudinal design. Longitudinal human studies are needed to describe the trajectory of nerve swelling for early identification of median nerve pathology.
Subjects:

Animals Carpal Tunnel Syndrome Disease Models, Animal Edema Humans Longitudinal Studies Macaca Fascicularis Median Nerve Motor Activity Occupational Diseases Reproducibility Of Results Research Design Sensitivity And Specificity Ultrasonography
Source:

Ultrasound Med Biol. 39(12):2492-2497.
Pubmed ID:

24139197
Pubmed Central ID:

PMC3834154
Document Type:

Journal Article
Funding:

K12 HD055929/HD/NICHD NIH HHS/United States ; R01 OH009131/OH/NIOSH CDC HHS/United States ; R21 OH009907/OH/NIOSH CDC HHS/United States
Volume:

39
Issue:

12
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:1be47edfa8fb35f0abffe8ee80e31ec2237ec2156f26596c634f395674fc1e55
Download URL:

https://stacks.cdc.gov/view/cdc/29782/cdc_29782_DS1.pdf
File Type:

[PDF - 284.30 KB ]

File Language:

English

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