Vitamin D in youth with Type 1 diabetes: prevalence of insufficiency and association with insulin resistance in the SEARCH Nutrition Ancillary Study

Details

• Alternative Title:
  Diabet Med
• Personal Author:
  The, N. S. ; Crandell, J. L. ; Lawrence, J. M. ; King, I. B. ; Dabelea, D. ; Marcovina, S. M. ; D’Agostino, R. B. ; Norris, J. M. ; Pihoker, C. ; Mayer-Davis, E. J.
• Description:
  Aims
  
  To determine the prevalence of plasma vitamin D insufficiency in individuals with Type 1 diabetes and to determine the cross-sectional and longitudinal associations of plasma vitamin D with insulin resistance.
  
  Methods
  
  Participants from the SEARCH for Diabetes in Youth Study [n = 1426; mean age 11.2 years (sd 3.9)] had physician-diagnosed Type 1 diabetes [diabetes duration mean 10.2 months (sd 6.5)] with data available at baseline and follow-up (approximately 12 and 24 months after baseline). Insulin resistance was estimated using a validated equation. Cross-sectional and longitudinal multivariate logistic regression models were used to determine the association of plasma vitamin D with insulin resistance, adjusting for potential confounders.
  
  Results
  
  Forty-nine per cent of individuals had plasma vitamin D < 50 nmol/l and 26% were insulin resistant. In cross-sectional multivariate analyses, participants who had higher plasma vitamin D (65 nmol/l) had lower odds of prevalent insulin resistance than participants with lower plasma vitamin D (25 nmol/l) (odds ratio 0.70, 95% CI 0.57–0.85). This association was attenuated after additional adjustment for BMI z-score, which could be a confounder or a mediator (odds ratio 0.81, 95% CI 0.64–1.03). In longitudinal multivariate analyses, individuals with higher plasma vitamin D at baseline had lower odds of incident insulin resistance, but this was not significant (odds ratio 0.85, 95% CI 0.63–1.14).
  
  Conclusions
  
  Vitamin D insufficiency is common in individuals with Type 1 diabetes and may increase risk for insulin resistance. Additional prospective studies are needed to determine the association between plasma vitamin D and insulin resistance, and to further examine the role of adiposity on this association.
  
  
• Subjects:
  Adolescent Child Diabetes Mellitus, Type 1 Epidemiologic Methods Female Humans Insulin Resistance Male Vitamin D Vitamin D Deficiency Young Adult

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• Source:
  Diabet Med. 30(11):1324-1332
• Pubmed ID:
  23909945
• Pubmed Central ID:
  PMC3822440
• Document Type:
  Journal Article
• Funding:
  P30 DK057516/DK/NIDDK NIH HHSUnited States/ ; U48/CCU419249/PHS HHSUnited States/ ; M01 RR000069/RR/NCRR NIH HHSUnited States/ ; U18DP002708-01/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000248/DP/NCCDPHP CDC HHSUnited States/ ; U48/CCU519239/PHS HHSUnited States/ ; U18DP002710-01/DP/NCCDPHP CDC HHSUnited States/ ; DK056350/DK/NIDDK NIH HHSUnited States/ ; P30DK57516/DK/NIDDK NIH HHSUnited States/ ; U01 DP000250/DP/NCCDPHP CDC HHSUnited States/ ; HIR 10-001/HX/HSRD VAUnited States/ ; 1U18DP002709/DP/NCCDPHP CDC HHSUnited States/ ; U48/CCU819241-3/PHS HHSUnited States/ ; M01RR00037/RR/NCRR NIH HHSUnited States/ ; U01 DP000247/DP/NCCDPHP CDC HHSUnited States/ ; R01 DK077949/DK/NIDDK NIH HHSUnited States/ ; U18 DP002710/DP/NCCDPHP CDC HHSUnited States/ ; U18DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000245/DP/NCCDPHP CDC HHSUnited States/ ; DP-05-069/DP/NCCDPHP CDC HHSUnited States/ ; U48/CCU919219/PHS HHSUnited States/ ; M01 RR000037/RR/NCRR NIH HHSUnited States/ ; DP-10-001/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000244/DP/NCCDPHP CDC HHSUnited States/ ; U58CCU919256/PHS HHSUnited States/ ; 00097/PHS HHSUnited States/ ; 1UL1RR026314-01/RR/NCRR NIH HHSUnited States/ ; U18DP000247-06A1/DP/NCCDPHP CDC HHSUnited States/ ; U01DP000247/DP/NCCDPHP CDC HHSUnited States/ ; UL1 RR029882/RR/NCRR NIH HHSUnited States/ ; M01 RR00069/RR/NCRR NIH HHSUnited States/ ; U58/CCU019235-4/PHS HHSUnited States/ ; U18 DP002709/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR001082/TR/NCATS NIH HHSUnited States/ ; P30 DK056350/DK/NIDDK NIH HHSUnited States/ ; U01 DP000246/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000254/DP/NCCDPHP CDC HHSUnited States/ ; UL1 RR026314/RR/NCRR NIH HHSUnited States/ ; U18 DP002708/DP/NCCDPHP CDC HHSUnited States/ ; UL1RR029882/RR/NCRR NIH HHSUnited States/
• Volume:
  30
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a9dcdd540d45cd4f620a8f0f14cc0e3ca34c7c9dd6b705a8460132685319cf73
• Download URL:
  https://stacks.cdc.gov/view/cdc/29770/cdc_29770_DS1.pdf
• File Type:
  [PDF - 285.95 KB ]