Vitamin D in youth with Type 1 diabetes: prevalence of insufficiency and association with insulin resistance in the SEARCH Nutrition Ancillary Study

The, N. S.; Crandell, J. L.; Lawrence, J. M.; King, I. B.; Dabelea, D.; Marcovina, S. M.; D’Agostino, R. B.; Norris, J. M.; Pihoker, C.; Mayer-Davis, E. J.

doi:10.1111/dme.12297

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Vitamin D in youth with Type 1 diabetes: prevalence of insufficiency and association with insulin resistance in the SEARCH Nutrition Ancillary Study

11 2013
By The, N. S. ; Crandell, J. L. ; Lawrence, J. M. ; ...
http://dx.doi.org/10.1111/dme.12297
Source: Diabet Med. 30(11):1324-1332

[PDF-285.95 KB]

English

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Details:

Alternative Title:

Diabet Med
Personal Author:

The, N. S. ; Crandell, J. L. ; Lawrence, J. M. ; King, I. B. ; Dabelea, D. ; ... More +

The, N. S. ; Crandell, J. L. ; Lawrence, J. M. ; King, I. B. ; Dabelea, D. ; Marcovina, S. M. ; D’Agostino, R. B. ; Norris, J. M. ; Pihoker, C. ; Mayer-Davis, E. J. Less -
Description:

Aims

To determine the prevalence of plasma vitamin D insufficiency in individuals with Type 1 diabetes and to determine the cross-sectional and longitudinal associations of plasma vitamin D with insulin resistance.

Methods

Participants from the SEARCH for Diabetes in Youth Study [n = 1426; mean age 11.2 years (sd 3.9)] had physician-diagnosed Type 1 diabetes [diabetes duration mean 10.2 months (sd 6.5)] with data available at baseline and follow-up (approximately 12 and 24 months after baseline). Insulin resistance was estimated using a validated equation. Cross-sectional and longitudinal multivariate logistic regression models were used to determine the association of plasma vitamin D with insulin resistance, adjusting for potential confounders.

Results

Forty-nine per cent of individuals had plasma vitamin D < 50 nmol/l and 26% were insulin resistant. In cross-sectional multivariate analyses, participants who had higher plasma vitamin D (65 nmol/l) had lower odds of prevalent insulin resistance than participants with lower plasma vitamin D (25 nmol/l) (odds ratio 0.70, 95% CI 0.57–0.85). This association was attenuated after additional adjustment for BMI z-score, which could be a confounder or a mediator (odds ratio 0.81, 95% CI 0.64–1.03). In longitudinal multivariate analyses, individuals with higher plasma vitamin D at baseline had lower odds of incident insulin resistance, but this was not significant (odds ratio 0.85, 95% CI 0.63–1.14).

Conclusions

Vitamin D insufficiency is common in individuals with Type 1 diabetes and may increase risk for insulin resistance. Additional prospective studies are needed to determine the association between plasma vitamin D and insulin resistance, and to further examine the role of adiposity on this association.
Subjects:

[+]

Adolescent Child Diabetes Mellitus, Type 1 Epidemiologic Methods Female Humans Insulin Resistance Male Vitamin D Vitamin D Deficiency Young Adult
Source:

Diabet Med. 30(11):1324-1332
Pubmed ID:

23909945
Pubmed Central ID:

PMC3822440
Document Type:

Journal Article
Funding:

P30 DK057516/DK/NIDDK NIH HHSUnited States/ ; U48/CCU419249/PHS HHSUnited States/ ; M01 RR000069/RR/NCRR NIH HHSUnited States/ ; U18DP002708-01/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002714/DP/NCCDPHP CDC HHSUnited States/ ; ... More +

P30 DK057516/DK/NIDDK NIH HHSUnited States/ ; U48/CCU419249/PHS HHSUnited States/ ; M01 RR000069/RR/NCRR NIH HHSUnited States/ ; U18DP002708-01/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000248/DP/NCCDPHP CDC HHSUnited States/ ; U48/CCU519239/PHS HHSUnited States/ ; U18DP002710-01/DP/NCCDPHP CDC HHSUnited States/ ; DK056350/DK/NIDDK NIH HHSUnited States/ ; P30DK57516/DK/NIDDK NIH HHSUnited States/ ; U01 DP000250/DP/NCCDPHP CDC HHSUnited States/ ; HIR 10-001/HX/HSRD VAUnited States/ ; 1U18DP002709/DP/NCCDPHP CDC HHSUnited States/ ; U48/CCU819241-3/PHS HHSUnited States/ ; M01RR00037/RR/NCRR NIH HHSUnited States/ ; U01 DP000247/DP/NCCDPHP CDC HHSUnited States/ ; R01 DK077949/DK/NIDDK NIH HHSUnited States/ ; U18 DP002710/DP/NCCDPHP CDC HHSUnited States/ ; U18DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000245/DP/NCCDPHP CDC HHSUnited States/ ; DP-05-069/DP/NCCDPHP CDC HHSUnited States/ ; U48/CCU919219/PHS HHSUnited States/ ; M01 RR000037/RR/NCRR NIH HHSUnited States/ ; DP-10-001/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000244/DP/NCCDPHP CDC HHSUnited States/ ; U58CCU919256/PHS HHSUnited States/ ; 00097/PHS HHSUnited States/ ; 1UL1RR026314-01/RR/NCRR NIH HHSUnited States/ ; U18DP000247-06A1/DP/NCCDPHP CDC HHSUnited States/ ; U01DP000247/DP/NCCDPHP CDC HHSUnited States/ ; UL1 RR029882/RR/NCRR NIH HHSUnited States/ ; M01 RR00069/RR/NCRR NIH HHSUnited States/ ; U58/CCU019235-4/PHS HHSUnited States/ ; U18 DP002709/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR001082/TR/NCATS NIH HHSUnited States/ ; P30 DK056350/DK/NIDDK NIH HHSUnited States/ ; U01 DP000246/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000254/DP/NCCDPHP CDC HHSUnited States/ ; UL1 RR026314/RR/NCRR NIH HHSUnited States/ ; U18 DP002708/DP/NCCDPHP CDC HHSUnited States/ ; UL1RR029882/RR/NCRR NIH HHSUnited States/ Less -
Volume:

30
Issue:

11
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:a9dcdd540d45cd4f620a8f0f14cc0e3ca34c7c9dd6b705a8460132685319cf73
Download URL:

https://stacks.cdc.gov/view/cdc/29770/cdc_29770_DS1.pdf
File Type:

nihms515598.nxml

xml

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