Random-access optical-resolution photoacoustic microscopy using a digital micromirror device

Liang, Jinyang; Zhou, Yong; Winkler, Amy W.; Wang, Lidai; Maslov, Konstantin I.; Li, Chiye; Wang, Lihong V.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Random-access optical-resolution photoacoustic microscopy using a digital micromirror device

Published Date:

Aug 1 2013

Source:

Opt Lett. 2013; 38(15):2683-2686.

[PDF-866.30 KB]

Details:

Personal Authors:

Liang, Jinyang ; Zhou, Yong ; Winkler, Amy W. ; Wang, Lidai ; Maslov, Konstantin I. ; ... More ▼

Keywords:

[+]

Pubmed ID:

23903111

Pubmed Central ID:

PMC3784350

Description:

We developed random-access optical-resolution photoacoustic microscopy using a digital micromirror device. This system can rapidly scan arbitrarily shaped regions of interest within a 40 μm×40 μm imaging area with a lateral resolution of 3.6 μm. To identify a region of interest, a global structural image is first acquired, then the selected region is scanned. The random-access ability was demonstrated by imaging two static samples, a carbon fiber cross and a monolayer of red blood cells, with an acquisition rate up to 4 kHz. The system was then used to monitor blood flow in vivo in real time within user-selected capillaries in a mouse ear. By imaging only the capillary of interest, the frame rate was increased by up to 9.2 times.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

Supporting Files:

	nihms507954f4.jpg	image/jpeg
	nihms507954f5.gif	image/gif
	nihms507954f5.jpg	image/jpeg
	nihms507954f6.gif	image/gif
	nihms507954f6.jpg	image/jpeg
	nihms507954.nxml	text/plain
	nihms507954f1.gif	image/gif
	nihms507954f1.jpg	image/jpeg
	nihms507954f2.gif	image/gif
	nihms507954f2.jpg	image/jpeg
	nihms507954f3.gif	image/gif
	nihms507954f3.jpg	image/jpeg
	nihms507954f4.gif	image/gif

No Related Documents.

You May Also Like:

Spatially Fourier-encoded photoacoustic microscopy using a digital micromirror device

Personal Author:

Liang, Jinyang; Gao, Liang; Li, Chiye; Wang, Lihong V.;

Published:

Feb 1 2014

Source:

Opt Lett. 2013; 39(3):430-433.

Description:

We have developed spatially Fourier-encoded photoacoustic (PA) microscopy using a digital micromirror device. The spatial intensity distribution of laser pulses is Fourier-encoded, and a series of such encoded PA measurements allows one to decode the...

File Type:

[PDF - 1.95 MB]
Calibration-free in vivo transverse blood flowmetry based on cross correlation of slow-time profiles from photoacoustic microscopy

Personal Author:

Zhou, Yong; Liang, Jinyang; Maslov, Konstantin I.; Wang, Lihong V.;

Published:

Oct 1 2013

Source:

Opt Lett. 2013; 38(19):3882-3885.

Description:

We propose a cross-correlation-based method to measure blood-flow velocity by using photoacoustic microscopy. Unlike in previous autocorrelation-based methods, the measured flow velocity here is independent of particle size. Thus an absolute flow vel...

File Type:

[PDF - 1.11 MB]
Amplitude-masked photoacoustic wavefront shaping and application in flowmetry

Personal Author:

Tay, Jian Wei; Liang, Jinyang; Wang, Lihong V.;

Published:

Oct 1 2014

Source:

Opt Lett. 2014; 39(19):5499-5502.

Description:

Optical-resolution photoacoustic flowmetry (PAF) allows noninvasive single-cell flow measurements. However, its operational depth is limited by optical diffusion, which prevents focusing beyond shallow depths in scattering media, as well as reducing ...

File Type:

[PDF - 896.97 KB]
Three-dimensional arbitrary trajectory scanning photoacoustic microscopy

Personal Author:

Yeh, Chenghung; Soetikno, Brian; Hu, Song; Maslov, Konstantin I.; Wang, Lihong V.;

Published:

Jul 30 2014

Source:

J Biophotonics. 2014; 8(4):303-308.

Description:

We have enhanced photoacoustic microscopy with three-dimensional arbitrary trajectory (3-DAT) scanning, which can rapidly image selected vessels over a large field of view (FOV) and maintain a high signal-to-noise ratio (SNR) despite the depth variat...

File Type:

[PDF - 842.32 KB]
Cuffing-based photoacoustic flowmetry in humans in the optical diffusive regime

Personal Author:

Zhou, Yong; Liang, Jinyang; Wang, Lihong V.;

Published:

Oct 30 2015

Source:

J Biophotonics. 9(3):208-212.

Description:

Measuring blood flow speed in the optical diffusive regime in humans has been a long standing challenge for photoacoustic tomography. In this work, we proposed a cuffing-based method to quantify blood flow speed in humans with a handheld photoacousti...

File Type:

[PDF - 739.15 KB]