Random-access optical-resolution photoacoustic microscopy using a digital micromirror device
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Published Date:Aug 01 2013
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Source:Opt Lett. 2013; 38(15):2683-2686.
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Language:English
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Personal Authors:
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Keywords:
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Pubmed ID:23903111
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Pubmed Central ID:PMC3784350
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Description:We developed random-access optical-resolution photoacoustic microscopy using a digital micromirror device. This system can rapidly scan arbitrarily shaped regions of interest within a 40 μm×40 μm imaging area with a lateral resolution of 3.6 μm. To identify a region of interest, a global structural image is first acquired, then the selected region is scanned. The random-access ability was demonstrated by imaging two static samples, a carbon fiber cross and a monolayer of red blood cells, with an acquisition rate up to 4 kHz. The system was then used to monitor blood flow in vivo in real time within user-selected capillaries in a mouse ear. By imaging only the capillary of interest, the frame rate was increased by up to 9.2 times.
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Document Type:
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Funding:T32 EB014855/EB/NIBIB NIH HHS/United States
R01 CA134539/CA/NCI NIH HHS/United States
R01 CA157277/CA/NCI NIH HHS/United States
U54 CA136398/CA/NCI NIH HHS/United States
R01 CA159959/CA/NCI NIH HHS/United States
R01 EB010049/EB/NIBIB NIH HHS/United States
DP1 EB016986/EB/NIBIB NIH HHS/United States
R01 EB008085/EB/NIBIB NIH HHS/United States
DP1 EB016986/DP/NCCDPHP CDC HHS/United States
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Supporting Files:
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