Evaluating the effects of maternal exposure to benzene, toluene, ethyl benzene, and xylene on oral clefts among offspring in Texas: 1999-2008

Ramakrishnan, Anushuya; Lupo, Philip J.; Agopian, A.J.; Linder, Stephen H.; Stock, Thomas H.; Langlois, Peter H.; Craft, Elena

doi:10.1002/bdra.23139

Advanced Search

Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

Advanced Search
Custom Query

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Clear All

Query Builder

Query box

Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Evaluating the effects of maternal exposure to benzene, toluene, ethyl benzene, and xylene on oral clefts among offspring in Texas: 1999-2008

8 2013
By Ramakrishnan, Anushuya ; Lupo, Philip J. ; Agopian, A.J. ; ...
http://dx.doi.org/10.1002/bdra.23139
Source: Birth Defects Res A Clin Mol Teratol. 97(8):532-537

[PDF-162.86 KB]

English

Details Supporting Files You May Also Like

Details:

Alternative Title:

Birth Defects Res A Clin Mol Teratol
Personal Author:

Ramakrishnan, Anushuya ; Lupo, Philip J. ; Agopian, A.J. ; Linder, Stephen H. ; Stock, Thomas H. ; ... More +

Ramakrishnan, Anushuya ; Lupo, Philip J. ; Agopian, A.J. ; Linder, Stephen H. ; Stock, Thomas H. ; Langlois, Peter H. ; Craft, Elena Less -
Description:

BACKGROUND

There is evidence from previous studies that maternal occupational exposure to hazardous air pollutants is positively associated with oral clefts, however, studies evaluating the association between residential exposure to these toxicants and oral clefts are lacking. Therefore, our goal was to conduct a case-control study examining the association between estimated maternal residential exposure to benzene, toluene, ethyl benzene, and xylene (BTEX) and the risk of oral clefts among offspring.

METHODS

Data on 6,045 non-syndromic isolated oral cleft cases (3,915 cleft lip with or without cleft palate [CL±P] and 2,130 non-syndromic isolated cleft palate [CP] cases) delivered between 1999 and 2008 were obtained from the Texas Birth Defects Registry. The control group was a sample of unaffected live births, frequency matched to cases on year of birth. Census tract-level estimates of annual average exposures were obtained from the U.S. Environmental Protection Agency 2005 Hazardous Air Pollutant Exposure Model (HAPEM5) for each pollutant and assigned to each subject based on maternal residence during pregnancy. Logistic regression was used to assess the relationship between estimated maternal exposure to each pollutant (benzene, toluene, ethyl benzene, and xylene) separately and the risk of oral clefts in offspring.

RESULTS

High estimated maternal exposure to benzene was not associated with oral clefts, compared with low estimated exposure (CL±P adjusted OR=0.95; 95% CI=0.81-1.12; CP adjusted OR=0.85; 95% CI=0.67-1.09). Similar results were seen for the other pollutants.

CONCLUSION

In our study, there was no evidence that maternal exposure to environmental levels of BTEX was associated with oral clefts.
Subjects:

[+]

Adult Air Pollutants Benzene Benzene Derivatives Brain Case-Control Studies Cleft Lip Cleft Palate Environmental Exposure Female Humans Male Maternal Exposure Pregnancy Risk Toluene Xylenes Young Adult
Keywords:

[+]

Benzene Epidemiology Hazardous Air Pollutants Maternal Exposure Oral Clefts
Source:

Birth Defects Res A Clin Mol Teratol. 97(8):532-537
Pubmed ID:

23893927
Pubmed Central ID:

PMC3771492
Document Type:

Journal Article
Funding:

R03 DE021739/DE/NIDCR NIH HHSUnited States/ ; U01 DD000494/DD/NCBDD CDC HHSUnited States/ ; U01DD000494/DD/NCBDD CDC HHSUnited States/ ; 1R03DE02173901A1/DE/NIDCR NIH HHSUnited States/

R03 DE021739/DE/NIDCR NIH HHSUnited States/ ; U01 DD000494/DD/NCBDD CDC HHSUnited States/ ; U01DD000494/DD/NCBDD CDC HHSUnited States/ ; 1R03DE02173901A1/DE/NIDCR NIH HHSUnited States/ Less -
Volume:

97
Issue:

8
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:bd5a706f8e4c3ebca933d77f255362b4695c635401819d0a0c8db97ea9466ca6
Download URL:

https://stacks.cdc.gov/view/cdc/29733/cdc_29733_DS1.pdf
File Type:

nihms-511822.nxml

xml

More +