Details:

Alternative Title:
Paediatr Perinat Epidemiol
Publisher's site:
http://dx.doi.org/10.1111/ppe.12055
Personal Author:
Padula, Amy M. ; Tager, Ira B. ; Carmichael, Suzan L. ; Hammond, S. Katharine ; Yang, Wei ; ... More +
Padula, Amy M. ; Tager, Ira B. ; Carmichael, Suzan L. ; Hammond, S. Katharine ; Yang, Wei ; Lurmann, Frederick ; Shaw, Gary M. Less -
Description:
Background

Congenital anomalies are a leading cause of infant morbidity and mortality. Studies suggest associations between environmental contaminants and some anomalies, although evidence is limited.

Methods

We used data from the California Center of the National Birth Defects Prevention Study and the Children's Health and Air Pollution Study to estimate the odds of 27 congenital heart defects with respect to quartiles of 7 ambient air pollutant and traffic exposures in California during the first two months of pregnancy, 1997–2006 (N=813 cases and N=828 controls).

Results

Particulate matter <10 microns (PM10) was associated with pulmonary valve stenosis (aOR4th Quartile=2.6; 95% CI: 1.2, 5.7) and perimembranous ventricular septal defects (aOR3rd Quartile=2.1; 95% CI: 1.1, 3.9) after adjusting for maternal race-ethnicity, education and multivitamin use. PM2.5 was associated with transposition of the great arteries (aOR3rd Quartile=2.6; 95% CI: 1.1, 6.5) and inversely associated with perimembranous ventricular septal defects (aOR4th Quartile=0.5; 95% CI: 0.2, 0.9). Secundum atrial septal defects were inversely associated with carbon monoxide (aOR4th Quartile=0.4; 95% CI: 0.2, 0.8) and PM2.5 (aOR4th Quartile=0.5; 95% CI: 0.3, 0.8). Traffic density was associated with muscular ventricular septal defects (aOR4th Quartile=3.0, 95% CI: 1.2, 7.8) and perimembranous ventricular septal defects (aOR3rd Quartile =2.4; 95% CI: 1.3, 4.6), and inversely associated with transposition of the great arteries (aOR4th Quartile=0.3; 95% CI: 0.1, 0.8).

Conclusions

PM10 and traffic density may contribute to the occurrence of pulmonary valve stenosis and ventricular septal defects, respectively. The results were mixed for other pollutants and had little consistency with previous studies.


Subject:
[+]
Adolescent
Adult
Air Pollutants
Air Pollution
Article
Carbon Monoxide
Environmental Exposure
Female
Heart Defects, Congenital
Heart Septal Defects
Humans
Infant, Newborn
Logistic Models
Male
Maternal Exposure
Motor Vehicles
Particulate Matter
Pregnancy
Pregnancy Outcome
Pulmonary Valve Stenosis
Vehicle Emissions
Young Adult

Source:
Paediatr Perinat Epidemiol. 27(4):329-339.
Document Type:
Journal Article
Funding:
6U01DD000489/DD/NCBDD CDC HHS/United States ; K99 ES021470/ES/NIEHS NIH HHS/United States ; L40 ES023163/ES/NIEHS NIH HHS/United States ; P20 ES018173/ES/NIEHS NIH HHS/United States
6U01DD000489/DD/NCBDD CDC HHS/United States ; K99 ES021470/ES/NIEHS NIH HHS/United States ; L40 ES023163/ES/NIEHS NIH HHS/United States ; P20 ES018173/ES/NIEHS NIH HHS/United States Less -
Place as Subject:
California
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:0e0a912aaf92bf2df4682c66f268badb1d3e296e5e0df654e0878969df9e275c
File Type:

Supporting Files

• nihms-457222.nxml

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