Americans’ Use of Dietary Supplements That Are Potentially Harmful in CKD

Details

• Alternative Title:
  Am J Kidney Dis
• Personal Author:
  Grubbs, Vanessa ; Plantinga, Laura C. ; Tuot, Delphine S. ; Hedgeman, Elizabeth ; Saran, Rajiv ; Saydah, Sharon ; Rolka, Deborah ; Powe, Neil R.
• Corporate Authors:
  Centers for Disease Control and Prevention CKD Surveillance Team
• Description:
  Background
  
  The prevalence in the United States of dietary supplement use that may be harmful to those with chronic kidney disease (CKD) is unknown. We sought to characterize potentially harmful supplement use by individual CKD status.
  
  Study Design
  
  Cross-sectional national survey (National Health and Nutrition Examination Survey, 1999-2008)
  
  Setting & Participants
  
  Community-based survey of 21,169 non-pregnant, non-institutionalized U.S. civilian adults (≥20 years)
  
  Predictor
  
  CKD status (no CKD, at risk for CKD [presence of diabetes, hypertension and/or cardiovascular disease], stage 1/2 [albuminuria only (albumin-creatinine ratio ≥30 mg/g)], or stage 3/4 [estimated glomerular filtration rate of 15-59 ml/min/1.73 m2]).
  
  Outcome
  
  Self-reported use of dietary supplements containing any of 37 herbs the National Kidney Foundation identified as potentially harmful in the setting of CKD.
  
  Measurements
  
  Albuminuria and estimated glomerular filtration rate assessed from urine and blood samples; demographics and comorbid conditions assessed by standardized questionnaire.
  
  Results
  
  An estimated 8.0% of U.S. adults reported potentially harmful supplement use within the last 30 days. Lower crude estimated prevalence of potentially harmful supplement use was associated with higher CKD severity (no CKD, 8.5%; at risk, 8.0%; stage 1/2, 6.1%; and stage 3/4, 6.2%; p<0.001). However, after adjustment for confounders, those with or at risk for CKD were as likely to use a potentially harmful supplement as those without CKD: at-risk OR, 0.93 (95% CI, 0.79 -1.09); stage 1/2 OR, 0.83 (95% CI, 0.64 -1.08); stage 3/4 OR, 0.87 (95% CI, 0.63 -1.18); all vs. no CKD.
  
  Limitations
  
  Herb content was not available and the list of potentially harmful supplements examined is unlikely to be exhaustive.
  
  Conclusions
  
  The use of dietary supplements potentially harmful to people with CKD is common, regardless of CKD status. Healthcare providers should discuss the use and potential risks of supplements with patients with and at risk for CKD.
  
  
• Subjects:
  Adult Aged Creatinine Cross-Sectional Studies Dietary Supplements Disease Progression Female Glomerular Filtration Rate Humans Male Middle Aged Nutrition Surveys Prevalence Renal Insufficiency, Chronic Risk Factors Surveys And Questionnaires Young Adult

  More +
• Source:
  Am J Kidney Dis. 2013; 61(5):739-747.
• Pubmed ID:
  23415417
• Pubmed Central ID:
  PMC3628413
• Document Type:
  Journal Article
• Funding:
  1U58DP003839-01/DP/NCCDPHP CDC HHS/United States ; K23 DK094850/DK/NIDDK NIH HHS/United States ; K24 DK002643/DK/NIDDK NIH HHS/United States ; KL2RR024130/RR/NCRR NIH HHS/United States ; R01 DK70939/DK/NIDDK NIH HHS/United States ; R01 DK78124/DK/NIDDK NIH HHS/United States ; T32 DK007219/DK/NIDDK NIH HHS/United States
• Place as Subject:
  United States
• Volume:
  61
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e934de74a87f9e95bdec52d543d627ae1f76d4d1cd3749636f4267a7a710551c
• Download URL:
  https://stacks.cdc.gov/view/cdc/29644/cdc_29644_DS1.pdf
• File Type:
  [PDF - 447.01 KB ]