Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2014.140759
Personal Author:
Teatero, Sarah ; McGeer, Allison ; Li, Aimin ; Gomes, Janice ; Seah, Christine ; ... More +
Teatero, Sarah ; McGeer, Allison ; Li, Aimin ; Gomes, Janice ; Seah, Christine ; Demczuk, Walter ; Martin, Irene ; Wasserscheid, Jessica ; Dewar, Ken ; Melano, Roberto G. ; Fittipaldi, Nahuel Less -
Description:
We recently showed that 37/600 (6.2%) invasive infections with group B Streptococcus (GBS) in Toronto, Ontario, Canada, were caused by serotype IV strains. We report a relatively high level of genetic diversity in 37 invasive strains of this emerging GBS serotype. Multilocus sequence typing identified 6 sequence types (STs) that belonged to 3 clonal complexes. Most isolates were ST-459 (19/37, 51%) and ST-452 (11/37, 30%), but we also identified ST-291, ST-3, ST-196, and a novel ST-682. We detected further diversity by performing whole-genome single-nucleotide polymorphism analysis and found evidence of recombination events contributing to variation in some serotype IV GBS strains. We also evaluated antimicrobial drug resistance and found that ST-459 strains were resistant to clindamycin and erythromycin, whereas strains of other STs were, for the most part, susceptible to these antimicrobial drugs.
Subject:
[+]
Adolescent
Adult
Aged
Age Distribution
Anti-Infective Agents
Child
Child, Preschool
Computational Biology
Drug Resistance, Bacterial
Genetic Variation
Humans
Infant
Infant, Newborn
Microbial Sensitivity Tests
Middle Aged
Multilocus Sequence Typing
Phylogeny
Population Surveillance
Serogroup
Streptococcal Infections
Streptococcus Agalactiae
Young Adult

Source:
Emerg Infect Dis. 21(4):585-591.
Document Type:
Journal Article
Place as Subject:
Toronto, Ontario
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:0145e93c13d48458f5f76bd509d8e2192ff00b585e28de0b2f9a002757606ce8
File Type:

Supporting Files

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  	14-0759-Techapp-s1.pdf	pdf
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