Epidemiology of Human Mycobacterium bovis Disease, California, USA, 2003–2011

Gallivan, Mark; Shah, Neha; Flood, Jennifer

doi:10.3201/eid2103.141539

i

Epidemiology of Human Mycobacterium bovis Disease, California, USA, 2003–2011

Supporting Files

Mar 2015
By Gallivan, Mark ; Shah, Neha ; Flood, Jennifer

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Gallivan, Mark ; Shah, Neha ; Flood, Jennifer
Description:

We conducted a retrospective review of California tuberculosis (TB) registry and genotyping data to evaluate trends, analyze epidemiologic differences between adult and child case-patients with Mycobacterium bovis disease, and identify risk factors for M. bovis disease. The percentage of TB cases attributable to M. bovis increased from 3.4% (80/2,384) in 2003 to 5.4% (98/1,808) in 2011 (p = 0.002). All (6/6) child case-patients with M. bovis disease during 2010-2011 had >1 parent/guardian who was born in Mexico, compared with 38% (22/58) of child case-patients with M. tuberculosis disease (p = 0.005). Multivariate analysis of TB case-patients showed Hispanic ethnicity, extrapulmonary disease, diabetes, and immunosuppressive conditions, excluding HIV co-infection, were independently associated with M. bovis disease. Prevention efforts should focus on Hispanic binational families and adults with immunosuppressive conditions. Collection of additional risk factors in the national TB surveillance system and expansion of whole-genome sequencing should be considered.
Subjects:

Adolescent Adult Aged Age Factors Antitubercular Agents/Pharmacology Child Child, Preschool Genotype Humans Incidence Infant Microbial Sensitivity Tests Middle Aged Mycobacterium Bovis/Drug Effects Mycobacterium Bovis/Genetics Mycobacterium Tuberculosis Population Surveillance Research Retrospective Studies Tuberculosis/Epidemiology Tuberculosis/Microbiology Young Adult
Source:

Emerg Infect Dis. 21(3):435-443.
Document Type:

Journal Article
Funding:

1U38HM000414/HM/NCHM CDC HHS/United States
Place as Subject:

California
Location:

North America
Volume:

21
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:a9a9de6efde913b1f5efc5bcefb83b59cf0385da5f1b8086a627b4fd58f4f0f3
Download URL:

https://stacks.cdc.gov/view/cdc/28115/cdc_28115_DS1.pdf
File Type:

[PDF - 528.11 KB ]

File Language:

English

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