A Carbonate-Forming Baeyer-Villiger Monooxygenase

Hu, Youcai; Dietrich, David; Xu, Wei; Patel, Ashay; Thuss, Justin A. J.; Wang, Jingjing; Yin, Wen-Bing; Qiao, Kangjian; Houk, Kendall N.; Vederas, John C.; Tang, Yi

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A Carbonate-Forming Baeyer-Villiger Monooxygenase

Published Date:

May 18 2014

Source:

Nat Chem Biol. 10(7):552-554.

[PDF - 664.66 KB]

Details:

Personal Authors:

Hu, Youcai ; Dietrich, David ; Xu, Wei ; Patel, Ashay ; Thuss, Justin A. J. ; ... More ▼

Keywords:

[+]

Pubmed ID:

24838010

Pubmed Central ID:

PMC4062580

Description:

Despite the remarkable versatility displayed by flavin-dependent monooxygenases (FMOs) in natural product biosynthesis, one notably missing activity is the oxidative generation of carbonate functional groups. We describe a multifunctional Baeyer-Villiger monooxygenase, CcsB, which catalyzes the formation of an in-line carbonate in the macrocyclic portion of cytochalasin E. This study expands the repertoire of activities of FMOs and provides a possible synthetic strategy for transformation of ketones into carbonates.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

1DP1GM106413/DP/NCCDPHP CDC HHS/United States
1R01GM085128/GM/NIGMS NIH HHS/United States
DP1 GM106413/GM/NIGMS NIH HHS/United States
R01 GM085128/GM/NIGMS NIH HHS/United States
T32GM008496/GM/NIGMS NIH HHS/United States

Supporting Files:

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