Details:

Alternative Title:
Genome Biol Evol
Publisher's site:
http://dx.doi.org/10.1093/gbe/evt198
Personal Author:
Ferreira, Zélia ; Hurle, Belen ; Andrés, Aida M. ; Kretzschmar, Warren W. ; Mullikin, James C. ; ... More +
Ferreira, Zélia ; Hurle, Belen ; Andrés, Aida M. ; Kretzschmar, Warren W. ; Mullikin, James C. ; Cherukuri, Praveen F. ; Cruz, Pedro ; Gonder, Mary Katherine ; Stone, Anne C. ; Tishkoff, Sarah ; Swanson, Willie J. ; Green, Eric D. ; Clark, Andrew G. ; Seixas, Susana Less -
Corporate Authors:
NISC Comparative Sequencing Program
Description:
Recent efforts have attempted to describe the population structure of common chimpanzee, focusing on four subspecies: Pan troglodytes verus, P. t. ellioti, P. t. troglodytes, and P. t. schweinfurthii. However, few studies have pursued the effects of natural selection in shaping their response to pathogens and reproduction. Whey acidic protein (WAP) four-disulfide core domain (WFDC) genes and neighboring semenogelin (SEMG) genes encode proteins with combined roles in immunity and fertility. They display a strikingly high rate of amino acid replacement (dN/dS), indicative of adaptive pressures during primate evolution. In human populations, three signals of selection at the WFDC locus were described, possibly influencing the proteolytic profile and antimicrobial activities of the male reproductive tract. To evaluate the patterns of genomic variation and selection at the WFDC locus in chimpanzees, we sequenced 17 WFDC genes and 47 autosomal pseudogenes in 68 chimpanzees (15 P. t. troglodytes, 22 P. t. verus, and 31 P. t. ellioti). We found a clear differentiation of P. t. verus and estimated the divergence of P. t. troglodytes and P. t. ellioti subspecies in 0.173 Myr; further, at the WFDC locus we identified a signature of strong selective constraints common to the three subspecies in WFDC6-a recent paralog of the epididymal protease inhibitor EPPIN. Overall, chimpanzees and humans do not display similar footprints of selection across the WFDC locus, possibly due to different selective pressures between the two species related to immune response and reproductive biology.
Subjects:
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Amino Acid Sequence Animals Base Sequence Evolution, Molecular Genetic Variation Humans Immunity, Innate Male Pan Troglodytes Polymorphism, Single Nucleotide Reproduction Selection, Genetic Seminal Vesicle Secretory Proteins Sequence Alignment Sequence Analysis, DNA
Source:
Genome Biol Evol. 2013; 5(12):2512-2523.
Pubmed ID:
24356879
Pubmed Central ID:
PMC3879984
Document Type:
Journal Article
Funding:
DP1 ES022577/DP/NCCDPHP CDC HHS/United States ; HD057974/HD/NICHD NIH HHS/United States ; WT097307/Wellcome Trust/United Kingdom
DP1 ES022577/DP/NCCDPHP CDC HHS/United States ; HD057974/HD/NICHD NIH HHS/United States ; WT097307/Wellcome Trust/United Kingdom Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:d444dbe7abf8e9c7210a923d6aac9a5fbd96fcdf639bc26db4f3c28c59f5cbd6
Download URL:
https://stacks.cdc.gov/view/cdc/27870/cdc_27870_DS1.pdf
File Type:

Supporting Files

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