Cryptosporidium parvum IId family: clonal population and dispersal from Western Asia to other geographical regions

Wang, Rongjun; Zhang, Longxian; Axén, Charlotte; Bjorkman, Camilla; Jian, Fuchun; Amer, Said; Liu, Aiqin; Feng, Yaoyu; Li, Guoquan; Lv, Chaochao; Zhao, Zifang; Qi, Meng; Dong, Haiju; Wang, Helei; Sun, Yanru; Ning, Changshen; Xiao, Lihua

doi:10.1038/srep04208

i

Cryptosporidium parvum IId family: clonal population and dispersal from Western Asia to other geographical regions

Supporting Files Public Domain

Feb 27 2014
By Wang, Rongjun ; Zhang, Longxian ; Axén, Charlotte ; ...

File Language:

English

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Sci Rep
Personal Author:

Wang, Rongjun ; Zhang, Longxian ; Axén, Charlotte ; Bjorkman, Camilla ; Jian, Fuchun ; Amer, Said ; Liu, Aiqin ; Feng, Yaoyu ; Li, Guoquan ; Lv, Chaochao ; Zhao, Zifang ; Qi, Meng ; Dong, Haiju ; Wang, Helei ; Sun, Yanru ; Ning, Changshen ; Xiao, Lihua
Description:

In this study, 111 Cryptosporidium parvum IId isolates from several species of animals in China, Sweden, and Egypt were subtyped by multilocus sequence typing (MLST). One to eleven subtypes were detected at each of the 12 microsatellite, minisatellite, and single nucleotide polymorphism (SNP) loci, forming 25 MLST subtypes. Host-adaptation and significant geographical segregation were both observed in the MLST subtypes. A clonal population structure was seen in C. parvum IId isolates from China and Sweden. Three ancestral lineages and the same RPGR sequence were shared by these isolates examined. Therefore, the present genetic observations including the higher nucleotide diversity of C. parvum IId GP60 sequences in Western Asia, as well as the unique distribution of IId subtypes (almost exclusively found in Asia, Europe, and Egypt) and in combination with the domestication history of cattle, sheep, and goats, indicated that C. parvum IId subtypes were probably dispersed from Western Asia to other geographical regions. More population genetic structure studies involving various C. parvum subtype families using high-resolution tools are needed to better elucidate the origin and dissemination of C. parvum in the world.
Subjects:

Cryptosporidium Parvum Genes, Protozoan Genetics, Population Genetic Variation Linkage Disequilibrium Minisatellite Repeats Molecular Sequence Data Multilocus Sequence Typing Phylogeny Phylogeography Polymorphism, Single Nucleotide
Source:

Sci Rep. 2014; 4.
Document Type:

Journal Article
Place as Subject:

China ; Egypt ; Sweden
Volume:

4
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:68cc5a9733fef14a030cf30a2acee8924c216ce87e9c21f58289f4fa6cc0402f
Download URL:

https://stacks.cdc.gov/view/cdc/27745/cdc_27745_DS1.pdf
File Type:

[PDF - 533.45 KB ]

File Language:

English

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