Details:

Alternative Title:
Tuberc Res Treat
Publisher's site:
http://dx.doi.org/10.1155/2014/217969
Personal Author:
Chuke, Stella O. ; Yen, Nguyen Thi Ngoc ; Laserson, Kayla F. ; Phuoc, Nguyen Huu ; Trinh, Nguyen An ; ... More +
Chuke, Stella O. ; Yen, Nguyen Thi Ngoc ; Laserson, Kayla F. ; Phuoc, Nguyen Huu ; Trinh, Nguyen An ; Nhung, Duong Thi Cam ; Mai, Vo Thi Chi ; Qui, An Dang ; Hai, Hoang Hoa ; Loan, Le Thien Huong ; Jones, Warren G. ; Whitworth, William C. ; Shah, J. Jina ; Painter, John A. ; Mazurek, Gerald H. ; Maloney, Susan A. Less -
Description:
Objective. Use of tuberculin skin tests (TSTs) and interferon gamma release assays (IGRAs) as part of tuberculosis (TB) screening among immigrants from high TB-burden countries has not been fully evaluated. Methods. Prevalence of Mycobacterium tuberculosis infection (MTBI) based on TST, or the QuantiFERON-TB Gold test (QFT-G), was determined among immigrant applicants in Vietnam bound for the United States (US); factors associated with test results and discordance were assessed; predictive values of TST and QFT-G for identifying chest radiographs (CXRs) consistent with TB were calculated. Results. Of 1,246 immigrant visa applicants studied, 57.9% were TST positive, 28.3% were QFT-G positive, and test agreement was 59.4%. Increasing age was associated with positive TST results, positive QFT-G results, TST-positive but QFT-G-negative discordance, and abnormal CXRs consistent with TB. Positive predictive values of TST and QFT-G for an abnormal CXR were 25.9% and 25.6%, respectively. Conclusion. The estimated prevalence of MTBI among US-bound visa applicants in Vietnam based on TST was twice that based on QFT-G, and 14 times higher than a TST-based estimate of MTBI prevalence reported for the general US population in 2000. QFT-G was not better than TST at predicting abnormal CXRs consistent with TB.
Subject:
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Research Article

Source:
Tuberc Res Treat. 2014; 2014.
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:4a34aada8b6b54476c4de3aae259f0dd9a56d8d6d7f264ed59978e79d8ac2f49
File Type:

Supporting Files

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  	TRT2014-217969.nxml	txt

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