Lagenidium giganteum Pathogenicity in Mammals

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Vilela, Raquel ; Taylor, John W. ; Walker, Edward D. ; Mendoza, Leonel
• Description:
  Infections of mammals by species in the phylum Oomycota taxonomically and molecularly similar to known Lagenidium giganteum strains have increased. During 2013-2014, we conducted a phylogenetic study of 21 mammalian Lagenidium isolates; we found that 11 cannot be differentiated from L. giganteum strains that the US Environmental Protection Agency approved for biological control of mosquitoes; these strains were later unregistered and are no longer available. L. giganteum strains pathogenic to mammals formed a strongly supported clade with the biological control isolates, and both types experimentally infected mosquito larvae. However, the strains from mammals grew well at 25°C and 37°C, whereas the biological control strains developed normally at 25°C but poorly at higher temperatures. The emergence of heat-tolerant strains of L. giganteum pathogenic to lower animals and humans is of environmental and public health concern.
• Subjects:
  Biological Control Dispatch Fungal-like Fungi Lagenidiosis Lagenidium Lagenidium Giganteum Lagenidium Giganteum Pathogenicity In Mammals Oomycetes Oomycota Pythiosis Pythium Insidiosum

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• Source:
  Emerg Infect Dis. 21(2):290-297.
• Document Type:
  Journal Article
• Volume:
  21
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:81b25f8ed081e6fb19d41bb87e0c352431ed0eefaaf16cec8480449684369d53
• Download URL:
  https://stacks.cdc.gov/view/cdc/27436/cdc_27436_DS1.pdf
• File Type:
  [PDF - 569.48 KB ]