Microbiota That Affect Risk for Shigellosis in Children in Low-Income Countries

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• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Lindsay, Brianna ; Oundo, Joe ; Hossain, M. Anowar ; Antonio, Martin ; Tamboura, Boubou ; Walker, Alan W. ; Paulson, Joseph N. ; Parkhill, Julian ; Omore, Richard ; Faruque, Abu S.G. ; Das, Suman Kumar ; Ikumapayi, Usman N. ; Adeyemi, Mitchell ; Sanogo, Doh ; Saha, Debasish ; Sow, Samba ; Farag, Tamer H. ; Nasrin, Dilruba ; Li, Shan ; Panchalingam, Sandra ; Levine, Myron M. ; Kotloff, Karen ; Magder, Laurence S. ; Hungerford, Laura ; Sommerfelt, Halvor ; Pop, Mihai ; Nataro, James P. ; Stine, O. Colin
• Description:
  Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17-0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8-220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.-induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene.
• Subjects:
  Age Factors Biodiversity Case-Control Studies Child, Preschool Developing Countries Diarrhea Dysentery, Bacillary Feces Gastrointestinal Tract Genes, Bacterial Humans Infant Infant, Newborn Metagenome Microbiota Odds Ratio Research Risk Rna, Ribosomal, 16S Severity Of Illness Index Shigella

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• Source:
  Emerg Infect Dis. 21(2):242-250.
• Document Type:
  Journal Article
• Volume:
  21
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:4753b0bf9329aaf4417bfe75713f609488671aceaf723116b75925a9fda567a3
• Download URL:
  https://stacks.cdc.gov/view/cdc/27424/cdc_27424_DS1.pdf
• File Type:
  [PDF - 818.72 KB ]