Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2102.140623
Personal Author:
Lau, Susanna K.P. ; Wu, Alan K.L. ; Teng, Jade L.L. ; Tse, Herman ; Curreem, Shirly O.T. ; ... More +
Lau, Susanna K.P. ; Wu, Alan K.L. ; Teng, Jade L.L. ; Tse, Herman ; Curreem, Shirly O.T. ; Tsui, Stephen K.W. ; Huang, Yi ; Chen, Jonathan H.K. ; Lee, Rodney A. ; Yuen, Kwok-Yung ; Woo, Patrick C.Y. Less -
Description:
Elizabethkingia anophelis, recently discovered from mosquito gut, is an emerging bacterium associated with neonatal meningitis and nosocomial outbreaks. However, its transmission route remains unknown. We use rapid genome sequencing to investigate 3 cases of E. anophelis sepsis involving 2 neonates who had meningitis and 1 neonate's mother who had chorioamnionitis. Comparative genomics revealed evidence for perinatal vertical transmission from a mother to her neonate; the 2 isolates from these patients, HKU37 and HKU38, shared essentially identical genome sequences. In contrast, the strain from another neonate (HKU36) was genetically divergent, showing only 78.6% genome sequence identity to HKU37 and HKU38, thus excluding a clonal outbreak. Comparison to genomes from mosquito strains revealed potential metabolic adaptations in E. anophelis under different environments. Maternal infection, not mosquitoes, is most likely the source of neonatal E. anophelis infections. Our findings highlight the power of genome sequencing in gaining rapid insights on transmission and pathogenesis of emerging pathogens.
Subjects:
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Bacteria Child Elizabethkingia Anophelis Evidence For Elizabethkingia Anophelis Transmission From Mother To Infant, Hong Kong Genome Hong Kong Maternal Meningitis Mother Neonatal Research Sepsis Sequencing Transmission Vertical
Source:
Emerg Infect Dis. 21(2):232-241.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:82d979f1d3571f1b354ddc5a30e5f170ccafad167c4ed310e546f9d1500e6a18
Download URL:
https://stacks.cdc.gov/view/cdc/27420/cdc_27420_DS1.pdf
File Type:

Supporting Files

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