Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2102.131879
Personal Author:
Hawken, Steven ; Kwong, Jeffrey C. ; Deeks, Shelley L. ; Crowcroft, Natasha S. ; McGeer, Allison J. ; ... More +
Hawken, Steven ; Kwong, Jeffrey C. ; Deeks, Shelley L. ; Crowcroft, Natasha S. ; McGeer, Allison J. ; Ducharme, Robin ; Campitelli, Michael A. ; Coyle, Doug ; Wilson, Kumanan ; Less -
Description:
It is unclear whether seasonal influenza vaccination results in a net increase or decrease in the risk for Guillain-Barré syndrome (GBS). To assess the effect of seasonal influenza vaccination on the absolute risk of acquiring GBS, we used simulation models and published estimates of age- and sex-specific risks for GBS, influenza incidence, and vaccine effectiveness. For a hypothetical 45-year-old woman and 75-year-old man, excess GBS risk for influenza vaccination versus no vaccination was -0.36/1 million vaccinations (95% credible interval -1.22 to 0.28) and -0.42/1 million vaccinations (95% credible interval, -3.68 to 2.44), respectively. These numbers represent a small absolute reduction in GBS risk with vaccination. Under typical conditions (e.g. influenza incidence rates >5% and vaccine effectiveness >60%), vaccination reduced GBS risk. These findings should strengthen confidence in the safety of influenza vaccine and allow health professionals to better put GBS risk in context when discussing influenza vaccination with patients.
Subject:
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Decision Tree Modeling
Guillain-Barré Syndrome
Influenza
Influenza Vaccination
Modeling
Research
Risk Modeling
Seasonal Influenza
Simulation Study Of The Effect Of Influenza And Influenza Vaccination On Risk Of Acquiring Guillain-Barré Syndrome
Vaccination
Viruses

Source:
Emerg Infect Dis. 21(2):224-231. ;
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:5532524d16dcdb50ff56e7d4bd266490b71b33fea59110e371f0d5006168a2d3
File Type:

Supporting Files

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  	13-1879-F1.gif	gif
  	13-1879-F1.jpg	jpeg
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  	13-1879-Techapp-s1.pdf	pdf
  	13-1879.nxml	txt

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