Divergent Picobirnaviruses in Human Feces

Details

• Alternative Title:
  Genome Announc
• Personal Author:
  Ng, Terry Fei Fan ; Vega, Everardo ; Kondov, Nikola O. ; Markey, Christopher ; Deng, Xutao ; Gregoricus, Nicole ; Vinjé, Jan ; Delwart, Eric
• Description:
  The near-complete genomes of two picobirnaviruses (PBVs) in diarrheal stool samples, human picobirnaviruses D and E (HuPBV-D and -E), were genetically characterized. Their RNA-dependent RNA polymerase (RdRp) protein sequences had <66% identities to known PBVs. Due to a single nucleotide insertion, the open reading frame 2 (ORF2) in segment 1 of HuPBV-D was interrupted by a stop codon. A small stem-loop structure overlying the stop codon may result in translational readthrough into the rest of ORF2.
• Subjects:
  Viruses
• Source:
  Genome Announc. 2014; 2(3).
• Document Type:
  Journal Article
• Funding:
  R01 HL105770/HL/NHLBI NIH HHS/United States
• Volume:
  2
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:bc15cb397518567ebbbb87bb5d34a4efbaefd61cae1cd9e3a972babefb4b7ebe
• Download URL:
  https://stacks.cdc.gov/view/cdc/27329/cdc_27329_DS1.pdf
• File Type:
  [PDF - 142.23 KB ]