Details:

Alternative Title:
PLoS Negl Trop Dis
Personal Author:
Kamuyu, Gathoni ; Bottomley, Christian ; Mageto, James ; Lowe, Brett ; Wilkins, Patricia P. ; ... More +
Kamuyu, Gathoni ; Bottomley, Christian ; Mageto, James ; Lowe, Brett ; Wilkins, Patricia P. ; Noh, John C. ; Nutman, Thomas B. ; Ngugi, Anthony K. ; Odhiambo, Rachael ; Wagner, Ryan G. ; Kakooza-Mwesige, Angelina ; Owusu-Agyei, Seth ; Ae-Ngibise, Kenneth ; Masanja, Honorati ; Osier, Faith H. A. ; Odermatt, Peter ; Newton, Charles R. Less -
Corporate Authors:
on behalf of the Study of Epidemiology of Epilepsy in Demographic Sites (SEEDS) group
Description:
Background

Epilepsy is common in developing countries, and it is often associated with parasitic infections. We investigated the relationship between exposure to parasitic infections, particularly multiple infections and active convulsive epilepsy (ACE), in five sites across sub-Saharan Africa.

Methods and Findings

A case-control design that matched on age and location was used. Blood samples were collected from 986 prevalent cases and 1,313 age-matched community controls and tested for presence of antibodies to Onchocerca volvulus, Toxocara canis, Toxoplasma gondii, Plasmodium falciparum, Taenia solium and HIV. Exposure (seropositivity) to Onchocerca volvulus (OR = 1.98; 95%CI: 1.52–2.58, p<0.001), Toxocara canis (OR = 1.52; 95%CI: 1.23–1.87, p<0.001), Toxoplasma gondii (OR = 1.28; 95%CI: 1.04–1.56, p = 0.018) and higher antibody levels (top tertile) to Toxocara canis (OR = 1.70; 95%CI: 1.30–2.24, p<0.001) were associated with an increased prevalence of ACE. Exposure to multiple infections was common (73.8% of cases and 65.5% of controls had been exposed to two or more infections), and for T. gondii and O. volvulus co-infection, their combined effect on the prevalence of ACE, as determined by the relative excess risk due to interaction (RERI), was more than additive (T. gondii and O. volvulus, RERI = 1.19). The prevalence of T. solium antibodies was low (2.8% of cases and 2.2% of controls) and was not associated with ACE in the study areas.

Conclusion

This study investigates how the degree of exposure to parasites and multiple parasitic infections are associated with ACE and may explain conflicting results obtained when only seropositivity is considered. The findings from this study should be further validated.


Subjects:
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Adolescent Adult Antibodies, Helminth Antibodies, Protozoan Case-Control Studies Child Child, Preschool Epilepsy Female Humans Infant Male Middle Aged Parasitic Diseases Prevalence Seroepidemiologic Studies Young Adult
Source:
PLoS Negl Trop Dis. 2014; 8(5).
Document Type:
Journal Article
Funding:
083744/Wellcome Trust/United Kingdom ; 084538/Wellcome Trust/United Kingdom ; 092654/Wellcome Trust/United Kingdom ; 095009/Wellcome Trust/United Kingdom ; 096392/Wellcome Trust/United Kingdom
083744/Wellcome Trust/United Kingdom ; 084538/Wellcome Trust/United Kingdom ; 092654/Wellcome Trust/United Kingdom ; 095009/Wellcome Trust/United Kingdom ; 096392/Wellcome Trust/United Kingdom Less -
Place as Subject:
Africa South of the Sahara
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a3eb61324921b9711ff3729d79520c73c608985ed5a82181b376e7f0adc56eff
Download URL:
https://stacks.cdc.gov/view/cdc/27302/cdc_27302_DS1.pdf
File Type:

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