Details:

Alternative Title:
Nutrients
Publisher's site:
http://dx.doi.org/10.3390/nu6125434
Personal Author:
Nordgren, Tara M. ; Friemel, Taylor D. ; Heires, Art J. ; Poole, Jill A. ; Wyatt, Todd A. ; ... More +
Nordgren, Tara M. ; Friemel, Taylor D. ; Heires, Art J. ; Poole, Jill A. ; Wyatt, Todd A. ; Romberger, Debra J. Less -
Description:
Workers exposed to organic dusts from concentrated animal feeding operations (CAFOs) are at risk for developing airway inflammatory diseases. Available preventative and therapeutic measures for alleviating dust-induced lung disease are inadequate. Because omega-3 fatty acids can mitigate inflammatory processes, we aimed to determine whether nutritional supplementation with the omega-3 fatty acid docosahexaenoic acid (DHA) could reduce the airway inflammatory consequences of exposures to organic dust. Aqueous extracts of organic dusts from swine CAFOs (ODE) were utilized. In DHA-pretreated human bronchial epithelial cells, lung fibroblasts, monocyte cell cultures, and precision-cut murine lung slices, we found that DHA pretreatment dose-dependently decreased ODE-induced inflammatory cytokine production. To determine the in vivo significance of DHA, C57BL/6 mice were orally administered DHA for seven days prior to treatment with intranasal ODE or saline inhalations. Animals treated with 2 mg DHA demonstrated significant reductions in ODE-induced bronchial alveolar lavage neutrophil influx and pro-inflammatory cytokine/chemokine production compared to mice exposed to ODE alone. Collectively, these data demonstrate that DHA affects several lung cells to reduce the airway inflammatory response to organic dust exposures. Dietary supplementation with DHA may be an effective therapeutic strategy to reduce the airway inflammatory consequences in individuals exposed to agriculture dust environments.
Subject:
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Airway Inflammation
Article
Docosahexaenoic Acid (DHA)
Organic Dust
Specialized Pro-resolving Mediators (SPM)

Source:
Nutrients. 2014; 6(12):5434-5452.
Pubmed ID:
25436433
Pubmed Central ID:
PMC4276977
Document Type:
Journal Article
Funding:
NIH-NIEHS F32-ES022913/ES/NIEHS NIH HHS/United States ; NIH-NIEHS R01-ES0193525/ES/NIEHS NIH HHS/United States ; NIH-NIOSH R01-0H008539/PHS HHS/United States ; NIH-NIOSH R01-OH010162/OH/NIOSH CDC HHS/United States ; NIOSH U54OH010162/OH/NIOSH CDC HHS/United States
NIH-NIEHS F32-ES022913/ES/NIEHS NIH HHS/United States ; NIH-NIEHS R01-ES0193525/ES/NIEHS NIH HHS/United States ; NIH-NIOSH R01-0H008539/PHS HHS/United States ; NIH-NIOSH R01-OH010162/OH/NIOSH CDC HHS/United States ; NIOSH U54OH010162/OH/NIOSH CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:078b05b7dd8bb7fdeef339e72e494e79353f29e68329ee288cad679d24c14540
File Type:

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