Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Booth, Malcolm ; Donaldson, Lindsay ; Cui, Xizhong ; Sun, Junfeng ; Cole, Stephen ; ... More +
Booth, Malcolm ; Donaldson, Lindsay ; Cui, Xizhong ; Sun, Junfeng ; Cole, Stephen ; Dailsey, Susan ; Hart, Andrew ; Johns, Neil ; McConnell, Paul ; McLennan, Tina ; Parcell, Benjamin ; Robb, Henry ; Shippey, Benjamin ; Sim, Malcolm ; Wallis, Charles ; Eichacker, Peter Q. Less -
Description:
In Scotland, the 2009 outbreak of Bacillus anthracis infection among persons who inject drugs resulted in a 28% death rate. To compare nonsurvivors and survivors, we obtained data on 11 nonsurvivors and 16 survivors. Time from B. anthracis exposure to symptoms or hospitalization and skin and limb findings at presentation did not differ between nonsurvivors and survivors. Proportionately more nonsurvivors had histories of excessive alcohol use (p = 0.05) and required vasopressors and/or mechanical ventilation (p≤0.01 for each individually). Nonsurvivors also had higher sequential organ failure assessment scores (mean ± SEM) (7.3 ± 0.9 vs. 1.2 ± 0.4, p<0.0001). Antibacterial drug administration, surgery, and anthrax polyclonal immune globulin treatments did not differ between nonsurvivors and survivors. Of the 14 patients who required vasopressors during hospitalization, 11 died. Sequential organ failure assessment score or vasopressor requirement during hospitalization might identify patients with injectional anthrax for whom limited adjunctive therapies might be beneficial.
Subject:
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Adult
Anthrax/diagnosis
Anthrax/drug Therapy
Anthrax/epidemiology
Anthrax/history
Anthrax/transmission
Bacillus Anthracis
Disease Outbreaks
Drug Users
History, 21st Century
Humans
Immune Sera
Public Health Surveillance
Risk Factors
Vasoconstrictor Agents

Source:
Emerg Infect Dis. 20(9):1452-1463.
Document Type:
Journal Article
Place as Subject:
Scotland
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:0a388fead6df42d911a42ba300e5e3262f99770e68a266d31c7b3688c8ecb7d6
File Type:

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