Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2101.131570
Personal Author:
Morris, Jodie ; Fane, Anne ; Rush, Catherine ; Govan, Brenda ; Mayo, Mark ; ... More +
Morris, Jodie ; Fane, Anne ; Rush, Catherine ; Govan, Brenda ; Mayo, Mark ; Currie, Bart J. ; Ketheesan, Natkunam Less -
Description:
The death rate for neurologic melioidosis is high. Whether certain Burkholderia pseudomallei strains are more likely than other strains to cause central nervous system infection and whether route of infection influences the neurotropic threat remain unclear. Therefore, we compared the virulence and dissemination of Australian clinical isolates collected during October 1989-October 2012 from patients with neurologic and nonneurologic melioidosis after intranasal and subcutaneous infection of mice in an experimental model. We did not observe neurotropism as a unique characteristic of isolates from patients with neurologic melioidosis. Rather, a distinct subset of B. pseudomallei strains appear to have heightened pathogenic potential for rapid dissemination to multiple tissues, including the central nervous system, irrespective of the infection route. This finding has valuable public health ramifications for initiating appropriate and timely therapy after exposure to systemically invasive B. pseudomallei strains. Increasing understanding of B. pseudomallei pathology and its influencing factors will further reduce illness and death from this disease.
Subject:
[+]
Bacteria
Bioterrorism
Burkholderia Pseudomallei
Central Nervous System
Melioidosis
Neurologic
Neurotropic Threat Characterization Of Burkholderia Pseudomallei Strains
Neurotropism
Research
Route Of Infection
Virulence

Source:
Emerg Infect Dis. 21(1):58-63.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:820a0f1895ae01a30e924fa6c4c94efcc9d46f0ee3ddb3597c78c24e4657ff13
File Type:

Supporting Files

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  	13-1570.nxml	txt
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