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Antiviral Treatment among Pregnant Women with Chronic Hepatitis B

Supporting Files Public Domain
File Language:
English


Details

  • Alternative Title:
    Infect Dis Obstet Gynecol
  • Personal Author:
  • Description:
    To describe the antiviral treatment patterns for chronic hepatitis B (CHB) among pregnant and nonpregnant women.|Using 2011 MarketScan claims, we calculated the rates of antiviral treatment among women (aged 10-50 years) with CHB. We described the pattern of antiviral treatment during pregnancy and ≥1 month after delivery.|We identified 6274 women with CHB during 2011. Among these, 64 of 507 (12.6%) pregnant women and 1151 of 5767 (20.0%) nonpregnant women received antiviral treatment (P < 0.01). Pregnant women were most commonly prescribed tenofovir (73.4%) and lamivudine (21.9%); nonpregnant women were most commonly prescribed tenofovir (50.2%) and entecavir (41.3%) (P < 0.01). Among 48 treated pregnant women with an identifiable delivery date, 16 (33.3%) were prescribed an antiviral before pregnancy and continued treatment for at least one month after delivery; 14 (29.2%) started treatment during the third trimester and continued at least one month after delivery.|Among this insured population, pregnant women with CHB received an antiviral significantly less often than nonpregnant women. The most common antiviral prescribed for pregnant women was tenofovir. These data provide a baseline for assessing changes in treatment patterns with anticipated increased use of antivirals to prevent breakthrough perinatal hepatitis B virus infection.
  • Subjects:
  • Source:
    Infect Dis Obstet Gynecol. 2014; 2014
  • Pubmed ID:
    25548510
  • Pubmed Central ID:
    PMC4274824
  • Document Type:
    Journal Article
  • Place as Subject:
    United States
  • Volume:
    2014
  • Collection(s):
  • Main Document Checksum:
    urn:sha256:271bfcf6455482b2c7ed4b79603910e8cf9b06de3284aff04bd9d33d1cd44ac6
  • Download URL:
  • File Type:
    Filetype[PDF - 544.76 KB ]
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