Antiviral Treatment among Pregnant Women with Chronic Hepatitis B
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Antiviral Treatment among Pregnant Women with Chronic Hepatitis B

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  • English

  • Details:

    • Alternative Title:
      Infect Dis Obstet Gynecol
    • Description:
      To describe the antiviral treatment patterns for chronic hepatitis B (CHB) among pregnant and nonpregnant women.|Using 2011 MarketScan claims, we calculated the rates of antiviral treatment among women (aged 10-50 years) with CHB. We described the pattern of antiviral treatment during pregnancy and ≥1 month after delivery.|We identified 6274 women with CHB during 2011. Among these, 64 of 507 (12.6%) pregnant women and 1151 of 5767 (20.0%) nonpregnant women received antiviral treatment (P < 0.01). Pregnant women were most commonly prescribed tenofovir (73.4%) and lamivudine (21.9%); nonpregnant women were most commonly prescribed tenofovir (50.2%) and entecavir (41.3%) (P < 0.01). Among 48 treated pregnant women with an identifiable delivery date, 16 (33.3%) were prescribed an antiviral before pregnancy and continued treatment for at least one month after delivery; 14 (29.2%) started treatment during the third trimester and continued at least one month after delivery.|Among this insured population, pregnant women with CHB received an antiviral significantly less often than nonpregnant women. The most common antiviral prescribed for pregnant women was tenofovir. These data provide a baseline for assessing changes in treatment patterns with anticipated increased use of antivirals to prevent breakthrough perinatal hepatitis B virus infection.
    • Source:
      Infect Dis Obstet Gynecol. 2014; 2014
    • Pubmed ID:
      25548510
    • Pubmed Central ID:
      PMC4274824
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