Details:

Alternative Title:
Travel Med Infect Dis
Personal Author:
Käser, Annina K. ; Arguin, Paul M. ; Chiodini, Peter L. ; Smith, Valerie ; Delmont, Jean ; ... More +
Käser, Annina K. ; Arguin, Paul M. ; Chiodini, Peter L. ; Smith, Valerie ; Delmont, Jean ; Jiménez, Beatriz C. ; Färnert, Anna ; Kimura, Mikio ; Ramharter, Michael ; Grobusch, Martin P. ; Schlagenhauf, Patricia Less -
Description:
Background

Data on imported malaria in pregnant women are scarce.

Method

A retrospective, descriptive study of pooled data on imported malaria in pregnancy was done, using data from 1977 to 2014 from 8 different collaborators in Europe, the United States and Japan. Most cases were from the period 1991–2014. National malaria reference centresas well as specialists on this topic were asked to search their archives for cases of imported malaria in pregnancy. A total of 632 cases were collated, providing information on Plasmodium species, region of acquisition, nationality, country of residence, reason for travel, age, gestational age, prophylactic measures and treatment used, as well as on complications and outcomes in mother and child.

Results

Datasets from some sources were incomplete. The predominant Plasmodium species was P. falciparum in 72% of cases. Among the 543 cases where information on the use of chemoprophylaxis was known, 471 (74.5%) did not use chemoprophylaxis or used incorrect or incomplete chemoprophylaxis. The main reason for travelling was “visiting friends and relatives” VFR (48.6%) and overall, most cases of malaria were imported from West Africa (85.9%). Severe anaemia was the most frequent complication in the mother. Data on offspring outcome was limited, but spontaneous abortion was a frequently reported foetal outcome (n = 14). A total of 50 different variants of malaria treatment regimens were reported.

Conclusion

Imported cases of malaria in pregnancy are mainly P. falciparum acquired in sub-Saharan Africa. Malaria prevention and treatment in pregnant travellers is a challenge for travel medicine due to few data on medication safety and maternal and foetal outcomes. International, collaborative efforts are needed to capture standardized data on imported malaria cases in pregnant women.


Subjects:
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Adolescent Adult Article Chemoprophylaxis Complications Female Humans Imported Malaria Malaria Middle Aged Pregnancy Pregnancy Complications, Infectious Retrospective Studies Travel Treatment Young Adult
Source:
Travel Med Infect Dis. 13(4):300-310
Pubmed ID:
26227740
Pubmed Central ID:
PMC4627431
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:adce623bfe1122e407b14e2fdb022b7b84abbcaed133a2640e3143436e2896ab
Download URL:
https://stacks.cdc.gov/view/cdc/36339/cdc_36339_DS1.pdf
File Type:

Supporting Files

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