Molecular Evolution of Peste des Petits Ruminants Virus

Muniraju, Murali; Munir, Muhammad; Parthiban, AravindhBabu R.; Banyard, Ashley C.; Bao, Jingyue; Wang, Zhiliang; Ayebazibwe, Chrisostom; Ayelet, Gelagay; El Harrak, Mehdi; Mahapatra, Mana; Libeau, Geneviève; Batten, Carrie; Parida, Satya

doi:10.3201/eid2012.140684

i

Molecular Evolution of Peste des Petits Ruminants Virus

Supporting Files Public Domain

Dec 2014
By Muniraju, Murali ; Munir, Muhammad ; Parthiban, AravindhBabu R. ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Muniraju, Murali ; Munir, Muhammad ; Parthiban, AravindhBabu R. ; Banyard, Ashley C. ; Bao, Jingyue ; Wang, Zhiliang ; Ayebazibwe, Chrisostom ; Ayelet, Gelagay ; El Harrak, Mehdi ; Mahapatra, Mana ; Libeau, Geneviève ; Batten, Carrie ; Parida, Satya
Description:

Despite safe and efficacious vaccines against peste des petits ruminants virus (PPRV), this virus has emerged as the cause of a highly contagious disease with serious economic consequences for small ruminant agriculture across Asia, the Middle East, and Africa. We used complete and partial genome sequences of all 4 lineages of the virus to investigate evolutionary and epidemiologic dynamics of PPRV. A Bayesian phylogenetic analysis of all PPRV lineages mapped the time to most recent common ancestor and initial divergence of PPRV to a lineage III isolate at the beginning of 20th century. A phylogeographic approach estimated the probability for root location of an ancestral PPRV and individual lineages as being Nigeria for PPRV, Senegal for lineage I, Nigeria/Ghana for lineage II, Sudan for lineage III, and India for lineage IV. Substitution rates are critical parameters for understanding virus evolution because restrictions in genetic variation can lead to lower adaptability and pathogenicity.
Subjects:

Bayesian Phylogenetics Divergence Emergence Evolution Measles Virus Molecular Evolution Of Peste Des Petits Ruminants Virus Nucleotide Substitution Rates Peste Des Petits Ruminants Virus Phylogeography PPRV Research Rinderpest Virus Selection Pressure Small Ruminants Time To Most Recent Common Ancestor TMRCA Viruses Wildlife
Source:

Emerg Infect Dis. 20(12):2023-2033.
Document Type:

Journal Article
Volume:

20
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:cbd3c58e2de9652e0890aca0807cb101465833665985fa3726154d9c3562cc8f
Download URL:

https://stacks.cdc.gov/view/cdc/26364/cdc_26364_DS1.pdf
File Type:

[PDF - 685.96 KB ]

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