Evolving Characteristics of Decedents With Hepatitis A Listed as a Cause of Death, United States, 2011-2021.

Details

• Alternative Title:
  Journal of Viral Hepatitis, 2024, v. 31, no. 12: Evolving Characteristics of Decedents With Hepatitis A Listed as a Cause of Death, United States, 2011-2021.
• Journal Article:
  Journal of Viral Hepatitis
• Personal Author:
  Hofmeister, Megan G. ; Ly, Kathleen N. ; Yin, Shaoman ; Spradling, Philip R.
• Description:
  Hepatitis A is a vaccine-preventable disease that typically causes mild illness. Hepatitis A outbreaks associated with person-to-person transmission have been widespread in the United States since 2016. We used public-use US Multiple Cause of Death data to compare characteristics and listed comorbidities among decedents with hepatitis A-listed deaths during non-outbreak (2011-2015) and outbreak (2017-2021) periods and assessed the median age at death among decedents with and without hepatitis A-listed deaths during the outbreak period. From the non-outbreak period to the outbreak period, hepatitis A-listed deaths more than doubled (from 369 to 801), while the hepatitis A-listed age-adjusted mortality rate increased 150% (p < 0.001). When compared with the non-outbreak period, hepatitis A-listed decedents during the outbreak period were more frequently male, aged 18-49 years, non-Hispanic White, died in an inpatient setting, and had hepatitis A listed as their underlying cause of death. The median age at death for hepatitis A-listed decedents was significantly younger during the outbreak period overall and among females (62 and 66 years, respectively) compared with the non-outbreak period (64 and 72 years, respectively, p < 0.001). During the outbreak period, median age at death for hepatitis A-listed decedents was 14 years younger than decedents without hepatitis A listed. Compared with the general US population, decedents with hepatitis A listed on the death certificate died at younger ages during 2017-2021. Efforts are needed to improve hepatitis A vaccination coverage among adults recommended for hepatitis A vaccination to prevent additional premature hepatitis A deaths.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Hepatitis A
  • Male
  • Female
  • Middle Aged
  • Adult
  • Young Adult
  • Adolescent
  • Aged
  • Cause of Death
  More +
• Keywords:
  • cause of death
  • hepatitis A virus
  • infectious disease outbreak
  • mortality
  • vaccine-preventable disease
• Source:
  Journal of Viral Hepatitis, 2024, v. 31, no. 12
• DOI:
  https://doi.org/10.1111/jvh.14002
• ISSN:
  1352-0504 ; 1365-2893
• Pubmed ID:
  39225298
• Pubmed Central ID:
  PMC11809443
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  783-794 (20 pdf pages)
• Volume:
  31
• Issue:
  12
• Download URL:
  https://stacks.cdc.gov/view/cdc/262033/cdc_262033_DS1.pdf
• File Type:
  [PDF - 434.45 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:5e4614edbc1d2de024fe403cb8ad22f3eb949be6d44e960e1c5509524dddb621b6a7860b9c9d6b04b72f00c7f1864118cf2ea73fcc6057d2cdd52c194330942c