Characterization of Pesticide Exposures and Their Associations With Asthma Morbidity in a Predominantly Low-income Urban Pediatric Cohort in Baltimore City.

Details

• Alternative Title:
  Environmental Research, 2024, v. 263, no. 2: Characterization of Pesticide Exposures and Their Associations With Asthma Morbidity in a Predominantly Low-income Urban Pediatric Cohort in Baltimore City.
• Journal Article:
  Environmental Research
• Personal Author:
  Fandiño-Del-Rio, Magdalena ; Tore, Grant ; Peng, Roger D. ; Meeker, John D. ; Matsui, Elizabeth C. ; Quirós-Alcalá, Lesliam
• Description:
  Pesticides may impact respiratory health, yet evidence of their impact on pediatric asthma morbidity is limited, particularly among urban children.
  
  To characterize pesticide biomarker concentrations and evaluate their associations with pediatric asthma morbidity among predominantly low-income, Black children in Baltimore City, USA.
  
  We measured urinary concentrations of 10 biomarkers for pyrethroid insecticides (cyfluthrin:4F-3PBA, permethrin:3PBA), organophosphate insecticides (chlorpyrifos:TCPY, malathion:MDA, parathion:PNP, diazinon:IMPY), and herbicides (glyphosate:AMPA, GPS; 2,4-dicholorphenoxyacetic acid:2,4-D; 2,4,5-tricholorphenoxyacetic acid:2,4,5-T) among 148 children (5-17 years) with established asthma. Urine samples and asthma morbidity measures (asthma symptoms, healthcare utilization, lung function and inflammation) were collected every three months for a year. Generalized estimating equations were used to examine associations between pesticide biomarker concentrations and asthma morbidity measures, controlling for age, sex, race, caregiver education, season, and environmental tobacco smoke. In sensitivity analyses, we assessed the robustness of our results after accounting for environmental co-exposures.
  
  Frequently detected (≥90% detection) pesticide biomarker concentrations (IMPY, 3PBA, PNP, TCPY, AMPA, GPS) varied considerably within children over the follow-up period (intraclass correlation coefficients: 0.1-0.2). Consistent positive significant associations were observed between the chlorpyrifos biomarker, TCPY, and asthma symptoms. Urinary concentrations of TCPY were associated with increased odds of coughing, wheezing, or chest tightness (adjusted Odds Ratio, aOR, TCPY:1.60, 95% Confidence Interval, CI:1.17-2.18). Urinary concentrations of TCPY were also associated with maximal symptom days (aOR:1.38, CI:1.02-1.86), exercise-related symptoms (aOR:1.63, CI:1.09-2.44), and hospitalizations for asthma (aOR:2.84, CI:1.08-7.43). We did not observe consistent evidence of associations between the pesticide exposures assessed and lung function or inflammation measures.
  
  Among predominantly Black children with asthma, we found evidence that chlorpyrifos is associated with asthma morbidity. Further research is needed to assess the contribution of pesticide exposures to pediatric respiratory health and characterize exposure sources among vulnerable populations to inform targeted interventions against potentially harmful pesticide exposures.
• Content Notes:
  Author manuscript
• Subjects:
  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Asthma
  • Biomarkers
  • Black or African American
  • Cohort Studies
  More +
• Keywords:
  • Pesticides
  • Respiratory Health
  • Exposure Assessment
  • Vulnerable Populations
• Source:
  Environmental Research, 2024, v. 263, no. 2
• DOI:
  https://doi.org/10.1016/j.envres.2024.120096
• ISSN:
  0013-9351 ; 1096-0953
• Pubmed ID:
  39362457
• Pubmed Central ID:
  PMC12143413
• Document Type:
  Text
• Funding:
  K01 HL138124/HL/NHLBI NIH HHSUnited States/ ; K24 AI114769/AI/NIAID NIH HHSUnited States/ ; T42 OH008428/OH/NIOSH CDC HHSUnited States/ ; R01 ES026170/ES/NIEHS NIH HHSUnited States/ ; P30 ES017885/ES/NIEHS NIH HHSUnited States/ ; R01 ES023447/ES/NIEHS NIH HHSUnited States/ ; P50 ES018176/ES/NIEHS NIH HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  Baltimore
• Pages in Document:
  120096 (24 pdf pages)
• Volume:
  263
• Issue:
  2
• Download URL:
  https://stacks.cdc.gov/view/cdc/262001/cdc_262001_DS1.pdf
• File Type:
  [PDF - 699.96 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:ace19ddd0775e7149ad88a7518a3b8287caa48d8a3f0cfd6d8286c6ae4367a3b04a19a2f974202ba91d4fbf2b2d17c4954e1c7315e7c1a05491ac171c0aa7041