Cytomegalovirus Urinary Excretion in Children With Congenital and Postnatally Acquired Infection.

Details

• Alternative Title:
  Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 2025, v. 176: Cytomegalovirus Urinary Excretion in Children With Congenital and Postnatally Acquired Infection.
• Journal Article:
  Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
• Personal Author:
  Lanzieri, Tatiana M. ; Caviness, A. Chantal ; Williams, Jill J. ; Demmler-Harrison, Gail
• Corporate Authors:
  the Houston Congenital Cytomegalovirus Longitudinal Study Group
• Description:
  Cytomegalovirus (CMV) infection in children is associated with prolonged viral excretion in urine and saliva. This study characterizes CMV urinary excretion in children with congenital (cCMV) and postnatally acquired CMV infection.
  
  Children with virologically confirmed cCMV (75 symptomatic and 105 asymptomatic at birth) and 51 children without cCMV were followed through median 11, 18 and 17 years of age, respectively. In children with cCMV, duration of CMV excretion was defined as uninterrupted positive results from initial to last positive culture, and recurrent CMV excretion as ≥1 positive following >1 negative result. CMV urinary excretion in children without cCMV was defined as resulting from postnatally acquired CMV infection.
  
  Mean duration of persistent CMV urinary excretion in children with cCMV was 1.9 (maximum 8.7) years for symptomatic and 2.8 (maximum 9.8) years for asymptomatic children (P = 0.011). Mean duration of CMV excretion was not statistically different for 17 symptomatic children treated with ganciclovir (2.4 years) compared with 58 untreated (1.8 years); P = 0.356. Recurrent excretion occurred in 19 (25 %) symptomatic and 21 (20 %) asymptomatic children, at mean age 4.0 and 6.2 years, respectively (P = 0.084). In 16 (31 %) children with postnatally acquired CMV infection, CMV urinary excretion began at mean age 1.8 (range 0.3-7.3) years.
  
  Both symptomatic and asymptomatic cCMV were associated with persistent long-term CMV excretion in urine, which was significantly longer in asymptomatic cCMV and not influenced by ganciclovir treatment in symptomatic cCMV. CMV urinary excretion was common in young children without cCMV, suggesting rapid CMV acquisition in childhood.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Cytomegalovirus Infections
  • Child
  • Cytomegalovirus
  • Adolescent
  • Female
  • Male
  • Child, Preschool
  • Infant
  • Virus Shedding
  More +
• Keywords:
  • Cytomegalovirus
  • congenital
  • urinary excretion
  • culture
• Source:
  Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 2025, v. 176
• DOI:
  https://doi.org/10.1016/j.jcv.2024.105756
• ISSN:
  1386-6532 ; 1873-5967
• Pubmed ID:
  39644592
• Pubmed Central ID:
  PMC12875390
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; M01 RR000188/RR/NCRR NIH HHSUnited States/ ; P30 HD024064/HD/NICHD NIH HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  105756 (14 pdf pages)
• Volume:
  176
• Download URL:
  https://stacks.cdc.gov/view/cdc/261875/cdc_261875_DS1.pdf
• File Type:
  [PDF - 415.74 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:8f5bc973f1e3ba1e0be437dde63dacf34cd42285811ef57fcba71d085de80f409f022cf7de5ea98379c0cb3d1065788d1b380490c303ff4a506299fd8569271e