High Prevalence of Asymptomatic CMV Shedding in Healthy Children Attending the Minnesota State Fair

Details

• Alternative Title:
  J Clin Virol
• Personal Author:
  Geris, Jennifer M. ; Spector, Logan G. ; Roesler, Michelle ; Hernandez-Alvarado, Nelmary ; Blackstad, Mark ; Nelson, Heather H. ; Schleiss, Mark R.
• Description:
  Background:
  
  Young children in the household are a known risk factor for maternal CMV infection and consequently, congenital infection in infants. However, little is known about viral shedding in pre-school aged children.
  
  Objectives:
  
  To estimate the prevalence of CMV DNA shedding and CMV antibodies among healthy children and their mothers.
  
  Study Design:
  
  A study of children ages 0 through 5 years was undertaken at the 2019 Minnesota State Fair. Children and their mothers were assessed for CMV shedding by procurement of a saliva swab for CMV PCR testing. An optional finger-stick for capillary blood was used to assess CMV antibodies.
  
  Results:
  
  A total of 109 children and 85 mothers were enrolled. The prevalence of CMV saliva shedding among children (mean age 3.1 years, SE=0.16) and their mothers was 12/109 (11.0%) and 1/85 (1.2%), respectively. The prevalence of CMV DNA among children peaked at 3 years of age (26%) while the mean viral load was greatest at one-year of age (236,693 IU/mL). CMV IgG antibodies among those who agreed to a finger-stick were detected in 16/35 mothers (45.7%) and 0/7 children (0%). Mothers of children aged 5 years or greater had the highest seroprevalence (61.5%).
  
  Conclusions:
  
  The prevalence of CMV salivary shedding in this unselected sample of young children was approximately 11.0%. The overall maternal seroprevalence in our sample was <50%, suggesting these women are at risk for acquisition of a primary CMV infection in subsequent pregnancies.
  
  
• Subjects:
  Antibodies, Viral Child Child, Preschool Cytomegalovirus Cytomegalovirus Infections Female Humans Infant Minnesota Pregnancy Prevalence Seroepidemiologic Studies Virus Shedding

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• Keywords:
  Asymptomatic Shedding CMV PCR Congenital CMV Cytomegalovirus (CMV)
• Source:
  J Clin Virol. 148:105102
• Pubmed ID:
  35158280
• Pubmed Central ID:
  PMC8918022
• Document Type:
  Journal Article
• Funding:
  T32 AI083196/AI/NIAID NIH HHSUnited States/ ; U19 DD001218/DD/NCBDD CDC HHSUnited States/ ; U19DD001218/ACL/ACL HHSUnited States/
• Volume:
  148
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3530a37b5e379c1df21dc1b2f8bc8923962607f5872ae5522ea351b3c3eda27b
• Download URL:
  https://stacks.cdc.gov/view/cdc/115446/cdc_115446_DS1.pdf
• File Type:
  [PDF - 764.59 KB ]