Prevalence of Hepatitis B Surface Antibody Among Previously Vaccinated Healthcare Workers in Tashkent, Uzbekistan.

Details

• Alternative Title:
  Human Vaccines & Immunotherapeutics, Dec-31-2024, v. 20, no. 1: Prevalence of Hepatitis B Surface Antibody Among Previously Vaccinated Healthcare Workers in Tashkent, Uzbekistan.
• Journal Article:
  Human Vaccines & Immunotherapeutics
• Personal Author:
  Ibragimov, Rafail ; Nabirova, Dilyara ; Denebaeva, Alfiya ; Kurbanov, Botirjon ; Horth, Roberta
• Description:
  Healthcare workers (HCW) have high occupational risk for hepatitis B and Uzbekistan held two HCW vaccination campaigns in 2015 and 2022. Hepatitis B antibody testing (anti-HBs) after Hepatitis B (HepB) vaccination is recommended by the U.S. CDC and WHO for HCW, but Uzbekistan does not have such a policy. In 2023, we randomly selected HCW from the campaign registries. Participants who agreed were interviewed at their workplaces. Vaccination doses were self-reported. Testing for hepatitis B surface antigen (HBsAg), Total hepatitis B core antibody (anti-HBc), and anti-HBs were concurrently performed. We used multivariable Poisson regression to assess factors associated with anti-HBs ≥10 mIU/mL. Of 334 participants, 205 were vaccinated in 2015 and 129 in 2022. Median age was 40 years (interquartile range 35-49 years), and 87% were female. Most (71%) reported having completed the three doses, 21% two doses and 7% one dose. Testing revealed that 5% had an active HBV infection, 4% had a resolved infection, and 91% had detectable vaccine-derived antibodies. Among those (
  
   = 303), 71% had anti-HBs ≥10 mIU/mL. For those who reported receiving 1, 2, and 3 doses, protective titers were 59%, 70%, and 72%, respectively. Protective titers were lower for HCW that worked in clinics versus hospitals (aPR = 0.92, CI: 0.87-0.98,
  
   = .01) adjusting for age, dose number and presence of chronic conditions. Strategies to improve completion of the 3-dose series and policies for post-vaccination immunity testing 1-2 months after completion of the 3-dose HepB series could help identify workers who may require revaccination or are currently infected.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Female
  • Hepatitis B Antibodies
  • Male
  • Middle Aged
  • Adult
  • Hepatitis B
  • Hepatitis B Vaccines
  • Health Personnel
  • Hepatitis B Surface Antigens
  More +
• Keywords:
  • Hepatitis B virus
  • immunization
  • vaccination
  • health personnel
  • hepatitis B antibodies
  • immunization programs
  • Uzbekistan
• Source:
  Human Vaccines & Immunotherapeutics, Dec-31-2024, v. 20, no. 1
• DOI:
  https://doi.org/10.1080/21645515.2024.2435142
• ISSN:
  2164-5515 ; 2164-554X
• Pubmed ID:
  39693189
• Pubmed Central ID:
  PMC11789720
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  Uzbekistan
• Pages in Document:
  2435142 (18 pdf pages)
• Volume:
  20
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/261845/cdc_261845_DS1.pdf
• File Type:
  [PDF - 477.94 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:c3947f8e90398f89366dfff7c57ea7cf3f663cd5e5e4846a9ac5a43a4184507d9164de3affdcc9f3efbe7f13ad5e8acf92128f363935bec2affeb0aae2413bb2