Comparison of Chlamydia Trachomatis Seroprevalence and Risk Factors For Infection Among Women by Gender/Sex of Sex Partner, United States, 2013-2016.

Details

• Alternative Title:
  Sexually Transmitted Diseases, 2025, v. 52, no. 6: Comparison of Chlamydia Trachomatis Seroprevalence and Risk Factors For Infection Among Women by Gender/Sex of Sex Partner, United States, 2013-2016.
• Journal Article:
  Sexually Transmitted Diseases
• Personal Author:
  Paris, Keely S. ; Khosropour, Christine M. ; Balkus, Jennifer E. ; Waters, Mary Bridget ; Kreisel, Kristen M. ; Manhart, Lisa E.
• Description:
  Women who report sex with women are thought to have a lower risk of Chlamydia trachomatis (CT) infection than women who report sex with men only (WSM-only), but comparisons of lifetime burden are limited.
  
  Among 1418 sexually experienced women aged 18 to 39 years participating in the National Health and Nutrition Examination Survey (2013-2016), we estimated weighted CT seroprevalence and Wald-based 95% confidence intervals (CIs) in women who reported ever having sex with a woman (all reported having sex with men also) (WSWM) compared with WSM-only. We defined seropositivity as detection of Pgp3 antibodies and used stratified Poisson regression with robust standard errors to estimate prevalence ratios (PRs).
  
  More than half (58.3%) were White non-Hispanic; 16.2% were WSWM. Women who had sex with women and men were somewhat younger (mean, 27.8 vs. 29.0 years; P = 0.07), were younger at sexual debut (mean, 15.6 vs. 17.5 years; P < 0.001), and had more lifetime male sexual partners (mean, 15.9 vs. 6.4; P < 0.001) than WSM-only. Weighted CT seroprevalence was 38.9% (95% CI, 30.4%-47.4%) in WSWM and 28.6% (95% CI, 24.4%-32.9%) in WSM-only. Correlates of higher CT seroprevalence in both groups were Black non-Hispanic race/ethnicity, Hispanic ethnicity, and CT infection in the prior year. Having ≥5 lifetime male partners compared with 1 to 2 partners was associated with higher seroprevalence among WSWM (PR, 4.5; 95% CI, 1.77-11.44) and WSM-only (PR, 2.7; 95% CI, 1.87-3.69). Among WSWM, bisexual identity was associated with lower seroprevalence. Among WSM-only, low income and younger age at sexual debut were associated with higher seroprevalence.
  
  Lifetime CT burden was higher in WSWM than WSM-only. Number of lifetime male partners was the strongest predictor of seropositivity for WSWM.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Female
  • Chlamydia Infections
  • Adult
  • Chlamydia trachomatis
  • Seroepidemiologic Studies
  • Risk Factors
  • Sexual Partners
  • Young Adult
  • Adolescent
  More +
• Keywords:
  • Chlamydia trachomatis
  • seroprevalence
  • women who have sex with women
  • sexual minority
• Source:
  Sexually Transmitted Diseases, 2025, v. 52, no. 6
• DOI:
  https://doi.org/10.1097/OLQ.0000000000002134
• ISSN:
  0148-5717 ; 1537-4521
• Pubmed ID:
  39718536
• Pubmed Central ID:
  PMC12184838
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; R01 AI161019/AI/NIAID NIH HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  325-332 (17 pdf pages)
• Volume:
  52
• Issue:
  6
• Download URL:
  https://stacks.cdc.gov/view/cdc/261828/cdc_261828_DS1.pdf
• File Type:
  [PDF - 157.69 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:bb1aae2a32493d4fd4e8e6c38c01ef9f3b98596f60f015fb701da167b622d11be5f63e4b36e25ef6995a453279164d84e0733a4bd46cdbbcff7cc5e927129214