Chlamydia trachomatis seroassays used in epidemiologic research: a narrative review and practical considerations

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Waters, Mary Bridget ; Hybiske, Kevin ; Ikeda, Ren ; Kaltenboeck, Bernhard ; Manhart, Lisa E. ; Kreisel, Kristen M. ; Khosropour, Christine M.
• Description:
  Chlamydia trachomatis (CT) is a sexually transmitted infection that can lead to adverse reproductive health outcomes. CT prevalence estimates are primarily derived from screening using nucleic acid amplification tests (NAATs). However, screening guidelines in the United States only include particular subpopulations, and NAATs only detect current infections. In contrast, seroassays identify past CT infections, which is important for understanding the public health impacts of CT, including pelvic inflammatory disease and tubal factor infertility. Older seroassays have been plagued by low sensitivity and specificity and have not been validated using a consistent reference measure, making it challenging to compare studies, define the epidemiology of CT, and determine the effectiveness of control programs. Newer seroassays have better performance characteristics. This narrative review summarizes the "state of the science" for CT seroassays that have been applied in epidemiologic studies and provides practical considerations for interpreting the literature and employing seroassays in future research.
• Subjects:
  Chlamydia Infections Chlamydia Trachomatis Epidemiologic Studies Female Humans Nucleic Acid Amplification Techniques Prevalence Sensitivity And Specificity United States
• Keywords:
  Antibodies Epidemiology Serology
• Source:
  J Infect Dis. 230(1):250-262
• Pubmed ID:
  39052727
• Pubmed Central ID:
  PMC11272089
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; R01AI161019/NH/NIH HHSUnited States/
• Volume:
  230
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:f3fdc274fd996564ddcafca55342bbcfa79eadbfb615ef044fd556364c429e5e3ffbd573e615539c2af3dd0de55caad1106b75e1ecd3c00e7fd135f0a236dbd4
• Download URL:
  https://stacks.cdc.gov/view/cdc/159415/cdc_159415_DS1.pdf
• File Type:
  [PDF - 108.56 KB ]