Evaluation of Drug-Drug Interactions in Pharmacoepidemiologic Research.

Details

• Alternative Title:
  Pharmacoepidemiology and Drug Safety, 2025, v. 34, no. 1: Evaluation of Drug-Drug Interactions in Pharmacoepidemiologic Research.
• Journal Article:
  Pharmacoepidemiology and Drug Safety
• Personal Author:
  Chen, Cheng ; Nguyen, Thanh Phuong Pham ; Hughes, John E. ; Hennessy, Sean ; Leonard, Charles E. ; Miano, Todd A. ; Douros, Antonios ; Gagne, Joshua J. ; Bykov, Katsiaryna
• Description:
  Drug-drug interactions (DDIs) represent a significant concern for clinical care and public health, but the health consequences of many DDIs remain largely underexplored. This knowledge gap underscores the critical need for pharmacoepidemiologic research to evaluate real-world health outcomes of DDIs. In this review, we summarize the definitions commonly used in pharmacoepidemiologic DDI studies, discuss common sources of bias, and illustrate through examples how these biases can be mitigated.
• Content Notes:
  Author manuscript
• Subjects:
  • Drug Interactions
  • Pharmacoepidemiology
  • Humans
  • Bias
  • Drug-Related Side Effects and Adverse Reactions
• Keywords:
  • Drug-drug interaction
  • design considerations
  • biases
  • methodology
  • study design
  • review
• Source:
  Pharmacoepidemiology and Drug Safety, 2025, v. 34, no. 1
• DOI:
  https://doi.org/10.1002/pds.70088
• ISSN:
  1053-8569 ; 1099-1557
• Pubmed ID:
  39805810
• Pubmed Central ID:
  PMC12074612
• Document Type:
  Text
• Funding:
  K01AG068365/NH/NIH HHSUnited States/ ; R01 DA048001/DA/NIDA NIH HHSUnited States/ ; RF1 NS132673/NS/NINDS NIH HHSUnited States/ ; R24 AG064025/AG/NIA NIH HHSUnited States/ ; R01AG060975/NH/NIH HHSUnited States/ ; R01CE003347/NH/NIH HHSUnited States/ ; R01MH130435/NH/NIH HHSUnited States/ ; R01 AG060975/AG/NIA NIH HHSUnited States/ ; R01 MH130435/MH/NIMH NIH HHSUnited States/ ; Heisenberg Program of the German Research Foundation/ ; K08DK124658/NH/NIH HHSUnited States/ ; R01HS027623/HS/AHRQ HHSUnited States/ ; K01 AG068365/AG/NIA NIH HHSUnited States/ ; R01 NS099129/NS/NINDS NIH HHSUnited States/ ; R01 CE003347/CE/NCIPC CDC HHSUnited States/ ; GOIPG/2021/1213/Irish Research Council Government of Ireland Postgraduate Scholarship Programme/ ; R01 HS027623/HS/AHRQ HHSUnited States/ ; K08 DK124658/DK/NIDDK NIH HHSUnited States/ ; R01DA048001/NH/NIH HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  e70088 (19 pdf pages)
• Volume:
  34
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/261773/cdc_261773_DS1.pdf
• File Type:
  [PDF - 761.86 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:953572ca6d4419433401966ca100f089e3226258da17715fe4153e1c4f5fc4abcf519d4052c3cf153894c207176181fcf72462e1572171a0a9b942aa413bd4a4