Details:

Alternative Title:
PLoS Negl Trop Dis
Publisher's site:
http://dx.doi.org/10.1371/journal.pntd.0003166
Personal Author:
Khan, Salah Uddin ; Salje, Henrik ; Hannan, A. ; Islam, Md. Atiqul ; Bhuyan, A. A. Mamun ; ... More +
Khan, Salah Uddin ; Salje, Henrik ; Hannan, A. ; Islam, Md. Atiqul ; Bhuyan, A. A. Mamun ; Islam, Md. Ariful ; Rahman, M. Ziaur ; Nahar, Nazmun ; Hossain, M. Jahangir ; Luby, Stephen P. ; Gurley, Emily S. Less -
Description:
Background

Japanese encephalitis (JE) virus infection can cause severe disease in humans, resulting in death or permanent neurologic deficits among survivors. Studies indicate that the incidence of JE is high in northwestern Bangladesh. Pigs are amplifying hosts for JE virus (JEV) and a potentially important source of virus in the environment. The objectives of this study were to describe the transmission dynamics of JEV among pigs in northwestern Bangladesh and estimate the potential impact of vaccination to reduce incidence among pigs.

Methodology/Principal Findings

We conducted a comprehensive census of pigs in three JE endemic districts and tested a sample of them for evidence of previous JEV infection. We built a compartmental model to describe JEV transmission dynamics in this region and to estimate the potential impact of pig vaccination. We identified 11,364 pigs in the study area. Previous JEV infection was identified in 30% of pigs with no spatial differences in the proportion of pigs that were seropositive across the study area. We estimated that JEV infects 20% of susceptible pigs each year and the basic reproductive number among pigs was 1.2. The model suggest that vaccinating 50% of pigs each year resulted in an estimated 82% reduction in annual incidence in pigs.

Conclusions/Significance

The widespread distribution of historic JEV infection in pigs suggests they may play an important role in virus transmission in this area. Future studies are required to understand the contribution of pig infections to JE risk in humans and the potential impact of pig vaccination on human disease.


Subjects:
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Animals Encephalitis, Japanese Female Japanese Encephalitis Vaccines Male Swine Swine Diseases Vaccination
Source:
PLoS Negl Trop Dis. 2014; 8(9).
Document Type:
Journal Article
Place as Subject:
Bangladesh
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:cc1729ba465debee26822110711469d3675803780a4222de48a4b047e41c9ab6
Download URL:
https://stacks.cdc.gov/view/cdc/26168/cdc_26168_DS1.pdf
File Type:

Supporting Files

• 	pntd.0003166.g003.jpg	jpeg
  	pntd.0003166.nxml	txt
  	pntd.0003166.s001.docx	docx
  	pntd.0003166.t001.gif	gif
  	pntd.0003166.t001.jpg	jpeg
  	pntd.0003166.t002.gif	gif
  	pntd.0003166.t002.jpg	jpeg
  	license.txt	txt
  	pntd.0003166.e001.jpg	jpeg
  	pntd.0003166.e002.jpg	jpeg
  	pntd.0003166.g001.gif	gif
  	pntd.0003166.g001.jpg	jpeg
  	pntd.0003166.g002.gif	gif
  	pntd.0003166.g002.jpg	jpeg
  	pntd.0003166.g003.gif	gif

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