Research Priorities of Individuals and Families With Sex Chromosome Aneuploidies.

Details

• Alternative Title:
  American Journal of Medical Genetics. Part A, 2025, v. 197, no. 6: Research Priorities of Individuals and Families With Sex Chromosome Aneuploidies.
• Journal Article:
  American Journal of Medical Genetics. Part A
• Personal Author:
  Carl, Alexandra ; Bothwell, Samantha ; Farah, Fathia ; Swenson, Karli ; Hong, David ; Prakash, Siddharth ; Strang, John ; Tartaglia, Nicole ; Raznahan, Armin ; Ross, Judith ; Davis, Shanlee
• Corporate Authors:
  INSIGHTS Consortium ; GALAXY Consortium
• Description:
  Sex chromosome aneuploidies (SCAs) are chromosomal variations that result from an atypical number of X and/or Y chromosomes. Combined, SCAs affect ~1/400 live births, including individuals with Klinefelter syndrome (47, XXY), Turner syndrome (45, X and variants), Double Y syndrome (47, XYY), Trisomy X (47, XXX), and rarer tetrasomies and pentasomies. Individuals with SCAs experience a wide variety of physical health, mental health, and healthcare experiences that differ from the standard population. To understand the priorities of the SCA community we surveyed participants in two large SCA registries, the Inspiring New Science in Guiding Healthcare in Turner Syndrome (INSIGHTS) Registry and the Generating Advancements in Longitudinal Analysis in X and Y Variations (GALAXY) Registry. 303/629 (48.1% response rate) individuals from 13 sites across the United States responded to the survey, including 251 caregivers and 52 self-advocates, with a range of ages from 3 weeks to 73 years old, and representation from all SCA groups (Turner syndrome, XXX, XXY, XYY, XXYY, and combined rare tetrasomies and pentasomies). Results demonstrate the priorities for physical health and emotional/behavioral health identified by the SCA community, as well as preferred types of research. All SCA subtypes indicated intervention studies as the top priority, emphasizing the need for researchers to focus on clinical treatments in response to priorities of the SCA community.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Female
  • Male
  • Aneuploidy
  • Adult
  • Middle Aged
  • Adolescent
  • Child
  • Child, Preschool
  • Aged
  More +
• Keywords:
  • Sex chromosome aneuploidies
  • Klinefelter syndrome
  • XXY
  • XYY
  • XXYY
  • Turner syndrome
  • Trisomy X
  • research priorities
• Source:
  American Journal of Medical Genetics. Part A, 2025, v. 197, no. 6
• DOI:
  https://doi.org/10.1002/ajmg.a.63998
• ISSN:
  1552-4825 ; 1552-4833
• Pubmed ID:
  39953941
• Pubmed Central ID:
  PMC12052495
• Document Type:
  Text
• Funding:
  R01 HD091251/HD/NICHD NIH HHSUnited States/ ; XXYY Project/ ; Turner Syndrome Global Alliance/ ; University of Colorado School of Medicine Department of Pediatrics/ ; Association for X and Y Chromosome Variations/ ; UM1 TR004399/TR/NCATS NIH HHSUnited States/ ; Living with XXY/ ; U01 DD001298/DD/NCBDD CDC HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  e63998 (22 pdf pages)
• Volume:
  197
• Issue:
  6
• Download URL:
  https://stacks.cdc.gov/view/cdc/261678/cdc_261678_DS1.pdf
• File Type:
  [PDF - 1.89 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:a99950499f596c3c1c487c97495484fde929840a3ba5426a828bf75ae579529090d716e167c287759609ccb7292ee19adb85de5a0a76e7cdfe152467f9cbf623