Behavioral Fluctuation in Disorders of Consciousness: a Retrospective Analysis.

Details

• Alternative Title:
  Archives of Physical Medicine and Rehabilitation, 2025, v. 106, no. 10: Behavioral Fluctuation in Disorders of Consciousness: a Retrospective Analysis.
• Journal Article:
  Archives of Physical Medicine and Rehabilitation
• Personal Author:
  Barra, Alice ; Bodien, Yelena G ; Tan, Can Ozan ; Martens, Geraldine ; Malone, Christopher ; Giacino, Joseph T
• Description:
  To assess the frequency of behavioral fluctuations in patients with prolonged disorders of consciousness (DoC), characterize the stability of consciousness ratings, and characterize the stability of behavioral signs of consciousness.
  
  Prospective observational analysis.
  
  Specialized DoC program in an inpatient rehabilitation facility and a long-term acute care hospital.
  
  Patients in a vegetative state/unresponsive wakefulness state, minimally conscious state, and emerging from a minimally conscious state followed weekly by the Coma Recovery Scale-Revised (CRS-R) between 28 and 90days postinjury (N=241).
  
  Change in CRS-R subscale scores and consciousness ratings.
  
  Behavioral fluctuation was observed in >80% of patients and was most common in the CRS-R motor subscale and least common in the communication subscale (83% and 54% of patients experienced ≥1 fluctuation over the 3wk study period, respectively, with a 1-point change observed most frequently). Among patients who were conscious at baseline assessment, 25% were subsequently rated as unconscious at least once. Localization to pain and object manipulation were the most stable signs of consciousness, recurring at least 3 times after the first occurrence in ≥97% of the sample. Reproducible command-following and intelligible verbalization were the least stable, recurring at least 3 times after the first occurrence in ≤27% of the sample.
  
  Patients with prolonged DoC who undergo serial assessment demonstrate a high rate of fluctuation in behavioral signs of consciousness. These findings highlight that repeated assessments are essential in this population, both to capture the highest level of consciousness and to help distinguish spontaneous fluctuation from response to treatment in interventional studies.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Male
  • Female
  • Middle Aged
  • Consciousness Disorders
  • Adult
  • Prospective Studies
  • Retrospective Studies
  • Aged
  • Persistent Vegetative State
• Keywords:
  • Disorders of consciousness
  • assessment scale
  • traumatic brain injury
  • rehabilitation
  • minimally conscious state
  • vegetative state
  • unresponsive wakefulness syndrome
• Source:
  Archives of Physical Medicine and Rehabilitation, 2025, v. 106, no. 10
• DOI:
  https://doi.org/10.1016/j.apmr.2025.03.038
• ISSN:
  0003-9993 ; 1532-821X
• Pubmed ID:
  40139629
• Pubmed Central ID:
  PMC12353754
• Document Type:
  Text
• Funding:
  R21 NS109627/NS/NINDS NIH HHSUnited States/ ; 90DPTB0027/ACL/ACL HHSUnited States/ ; U48 DP000039/DP/NCCDPHP CDC HHSUnited States/ ; RF1 NS115268/NS/NINDS NIH HHSUnited States/ ; DP2 HD101400/HD/NICHD NIH HHSUnited States/ ; U01 NS086090/NS/NINDS NIH HHSUnited States/ ; UH3 NS095554/NS/NINDS NIH HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  1505-1513 (21 pdf pages)
• Volume:
  106
• Issue:
  10
• Download URL:
  https://stacks.cdc.gov/view/cdc/261564/cdc_261564_DS1.pdf
• File Type:
  [PDF - 874.27 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:f4918753aa12bac75c15dd7e5155b1ed8cd75e6094bc742bcd5326d5681a14b8f2aa40efb36cc9a9cb40129e96ac11e9b87086478c1ccca503446da4192ff533