Gastroesophageal Reflux Disease in the World Trade Center Health Program General Responder Cohort.

Details

• Alternative Title:
  American Journal of Industrial Medicine, 2025, v. 68, no. 5: Gastroesophageal Reflux Disease in the World Trade Center Health Program General Responder Cohort.
• Journal Article:
  American Journal of Industrial Medicine
• Personal Author:
  Dasaro, Christopher R. ; Sabra, Ahmad ; Sacks, Henry S. ; Luft, Benjamin J. ; Harrison, Denise J. ; Udasin, Iris G. ; Crane, Michael A. ; Moline, Jacqueline M. ; Kwa, Winston ; Todd, Andrew C. ; Sloan, Nancy L. ; Teitelbaum, Susan L.
• Description:
  People participating in the rescue, recovery, and clean-up effort after the September 11, 2001 attack on the World Trade Center (WTC) were exposed to a complex mix of noxious substances and subsequently experienced elevated gastroesophageal reflux disease (GERD) incidence, the second-most-common WTC-related condition.
  
  Longitudinal WTC Health Program data, collected between July 2002 and December 2022, were used to describe the sample characteristics, diagnostic procedures, and treatment of consenting cohort members with self-reported GERD who reported incident GERD for a year or longer (n = 19,067). Cross-tabulations and binomial logistic regression, adjusted for confounders including comorbidities, assessed the associations with intermittent and resolved, compared with unresolved, GERD.
  
  12.6% of the study cohort reported intermittent GERD; 5.5% reported GERD resolution. Analyses indicated that most GERD resolution was reported by people of color and those with body mass index <25, and by cohort members who had longer postdiagnosis follow-up and implemented dietary modifications together with proton pump inhibitors or Program-approved antacids. GERD-certified members who underwent endoscopy, used medications without dietary modifications, or used bed head-elevation, and those with Barrett's disease (5.8%) or esophageal cancer (0.1%) may have had more severe GERD and reported little resolution.
  
  The use of GERD services was consistent with clinical guidelines. Members' implementing dietary modifications in conjunction with proton pump inhibitors or Program-approved antacids reported more resolution and may have had less severe GERD. Earlier diagnosis and intervention might increase earlier therapeutic resolution.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Gastroesophageal Reflux
  • Male
  • September 11 Terrorist Attacks
  • Female
  • Middle Aged
  • Adult
  • Incidence
  • Longitudinal Studies
  • Emergency Responders
  More +
• Keywords:
  • gastroesophageal reflux disease
  • GERD treatment
  • health service utilization
  • rescue/recovery work
  • World Trade Center
• Source:
  American Journal of Industrial Medicine, 2025, v. 68, no. 5
• DOI:
  https://doi.org/10.1002/ajim.23721
• ISSN:
  0271-3586 ; 1097-0274
• Pubmed ID:
  40176277
• Pubmed Central ID:
  PMC12757917
• Document Type:
  Text
• Funding:
  HHSD200200200384C/OH/NIOSH CDC HHSUnited States/ ; HHSD200201793325C/OH/NIOSH CDC HHSUnited States/ ; U10 OH008216/OH/NIOSH CDC HHSUnited States/ ; HHSD200201139356C/OH/NIOSH CDC HHSUnited States/ ; This work was supported by the Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health (cooperative agreements and contracts 200-2002-00384, U10-OH008216/23/25/32/39/75, 200-2011-39356/61/77/84/85/88, 200-2017-93325/28/29/30/31/32 and 75D30122C15187)./ ; HHSD200201139377C/OH/NIOSH CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  New York City
• Pages in Document:
  473-483 (19 pdf pages)
• Volume:
  68
• Issue:
  5
• Download URL:
  https://stacks.cdc.gov/view/cdc/261528/cdc_261528_DS1.pdf
• File Type:
  [PDF - 287.65 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:df86f5fedda69b3eee02e86332d0733c67dc442247af4334da62b69ddd87d2f58d0166285e42785451644e4aa28d7c0b170383cd0e3aba478d2d9b7f69e9b65a