Early Postnatal Polymerase Chain Reaction Testing in the Identification of Perinatal Transmission of Hepatitis C Virus.

Details

• Alternative Title:
  Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 2026, v. 81, no. 6: Early Postnatal Polymerase Chain Reaction Testing in the Identification of Perinatal Transmission of Hepatitis C Virus.
• Journal Article:
  Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America
• Personal Author:
  Prasad, Mona ; Sandoval, Grecio J. ; Saade, George R. ; Hughes, Brenna L. ; Clifton, Rebecca G. ; Reddy, Uma M. ; Bartholomew, Anna ; Salazar, Ashley ; Chien, Edward K. ; Tita, Alan T. N. ; Thorp, John M. ; Metz, Torri D. ; Wapner, Ronald J. ; Sabharwal, Vishakha ; Simhan, Hyagriv N. ; Swamy, Geeta K. ; Heyborne, Kent D. ; Sibai, Baha M. ; Grobman, William A. ; El-Sayed, Yasser Y. ; Casey, Brian M. ; Parry, Samuel ; Macones, George A.
• Description:
  In this study, a single hepatitis C virus (HCV) RNA at 2-6 months was sensitive and specific (86.7% and 95% confidence interval CI, 62.1%-96.3% and 100% and 95% CI, 98.8%-100%, respectively) in identifying perinatal transmission of HCV. No cases of perinatal infection requiring treatment were missed.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Infectious Disease Transmission, Vertical
  • Hepatitis C
  • Hepacivirus
  • Female
  • Infant, Newborn
  • RNA, Viral
  • Sensitivity and Specificity
  • Pregnancy
  • Polymerase Chain Reaction
  More +
• Keywords:
  • hepatitis C virus
  • HCV
  • perinatal transmission
  • PCR
  • pediatric screening
• Source:
  Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 2026, v. 81, no. 6
• DOI:
  https://doi.org/10.1093/cid/ciaf266
• ISSN:
  1058-4838 ; 1537-6591
• Pubmed ID:
  40653712
• Pubmed Central ID:
  PMC12285734
• Document Type:
  Text
• Funding:
  UG1 HD027869/HD/NICHD NIH HHSUnited States/ ; UH3 OD035546/OD/NIH HHSUnited States/ ; UG1 HD034116/HD/NICHD NIH HHSUnited States/ ; UG1 HD040560/HD/NICHD NIH HHSUnited States/ ; UG1 HD087230/HD/NICHD NIH HHSUnited States/ ; UG1 HD053097/HD/NICHD NIH HHSUnited States/ ; UG1 HD068258/HD/NICHD NIH HHSUnited States/ ; UG1 HD040545/HD/NICHD NIH HHSUnited States/ ; UG1 HD112063/HD/NICHD NIH HHSUnited States/ ; U24 HD036801/HD/NICHD NIH HHSUnited States/ ; CC/CDC HHSUnited States/ ; UG1 HD027915/HD/NICHD NIH HHSUnited States/ ; UG1 HD087192/HD/NICHD NIH HHSUnited States/ ; UG1 HD040544/HD/NICHD NIH HHSUnited States/ ; UG1 HD034208/HD/NICHD NIH HHSUnited States/ ; UG1 HD040512/HD/NICHD NIH HHSUnited States/ ; UG1 HD040485/HD/NICHD NIH HHSUnited States/ ; UG1 HD068268/HD/NICHD NIH HHSUnited States/ ; UG1 HD040500/HD/NICHD NIH HHSUnited States/ ; UG1 HD068282/HD/NICHD NIH HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  1102-1105 (7 pdf pages)
• Volume:
  81
• Issue:
  6
• Download URL:
  https://stacks.cdc.gov/view/cdc/261263/cdc_261263_DS1.pdf
• File Type:
  [PDF - 289.74 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:b97522f9b5697ed167a398f5052a9d15496d6b5ba7e0ff0b492df4549115e235fc8c816b58669ea7cf1133821f7a129f8a2fb62d61669b4b5860755fdf4e27cb