Systemic Toxicity Induced by Topical Application of the Sulfonic Acids, Perfluorobutane Sulfonic Acid (PFBS) and Perfluoropentane Sulfonic Acid (PFPeS), in a Murine Model.

Details

• Alternative Title:
  Toxicology and Applied Pharmacology, 2025, v. 503: Systemic Toxicity Induced by Topical Application of the Sulfonic Acids, Perfluorobutane Sulfonic Acid (PFBS) and Perfluoropentane Sulfonic Acid (PFPeS), in a Murine Model.
• Journal Article:
  Toxicology and Applied Pharmacology
• Personal Author:
  Cooper, Madison P. ; Weatherly, Lisa M. ; Lukomska, Ewa ; Jackson, Laurel G. ; Anderson, Stacey E.
• Description:
  Per- and polyfluoroalkyl substances (PFAS) are a large group of synthetic surfactants incorporated into products for their chemical and physical properties. Studies have associated PFAS with adverse health effects. Although there is a high potential for dermal exposure, toxicity studies related to this route of exposure are lacking. The present study evaluated the systemic toxicity following a sub-chronic 28-day dermal exposure to perfluorobutane sulfonic acid (PFBS) (1.25-5 %) or perfluoropentane sulfonic acid (PFPeS) (1.25-5 %) in a murine model. Elevated levels of both PFAS were detected in the serum and urine, suggesting that absorption occurs through the skin. Additionally, both PFAS induced significantly increased relative liver weight, altered serum chemistries, altered skin and liver histopathology, and significantly decreased relative spleen weight (PFPeS only). Gene expression changes were observed in the liver and skin for genes involved in fatty acid metabolism, inflammation, and skin integrity. In general, the PFPeS-induced changes in the endpoints examined were observed more frequently compared to PFBS, supporting the concept that longer-chain PFAS are more toxic. These findings support PFAS absorption through the skin, leading to liver damage and systemic toxicity.
• Content Notes:
  Author manuscript
• Subjects:
  • Animals
  • Fluorocarbons
  • Mice
  • Liver
  • Sulfonic Acids
  • Skin
  • Female
  • Male
  • Spleen
  • Administration, Cutaneous
  More +
• Keywords:
  • perfluorobutane sulfonic acid (PFBS)
  • perfluoropentane sulfonic acid (PFPeS)
  • toxicity
  • immune
  • dermal
  • liver damage
• Source:
  Toxicology and Applied Pharmacology, 2025, v. 503
• DOI:
  https://doi.org/10.1016/j.taap.2025.117487
• ISSN:
  0041-008X ; 1096-0333
• Pubmed ID:
  40714120
• Pubmed Central ID:
  PMC12360418
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; T32 ES032920/ES/NIEHS NIH HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  117487 (28 pdf pages)
• Volume:
  503
• Download URL:
  https://stacks.cdc.gov/view/cdc/261227/cdc_261227_DS1.pdf
• File Type:
  [PDF - 1.59 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:0f0d4d36ac1056703ce8aa4f4f7a1520531acabfa3808c4382e86d700af0d54a32608223032ed1b3e775a37a099404eb84a1aa8ceb90c18c3411b2acc1142ffe