Microbiota and Kidney Disease: the Road Ahead.

Details

• Alternative Title:
  Nature Reviews. Nephrology, 2025, v. 21, no. 10: Microbiota and Kidney Disease: the Road Ahead.
• Journal Article:
  Nature Reviews. Nephrology
• Personal Author:
  Bloom, Patricia P. ; Garrett, Wendy S. ; Penniston, Kristina L. ; Winkler, Mari-Karoliina H. ; Hazen, Stanley L. ; Agudelo, Jose ; Suryavanshi, Mangesh ; Babiker, Ahmed ; Dodd, Dylan ; Fischbach, Michael A. ; Huang, Kerwyn Casey ; Huttenhower, Curtis ; Joe, Bina ; Kalantar-Zadeh, Kamyar ; Knight, Rob ; Miller, Aaron W. ; Rabb, Hamid ; Srivastava, Anvesha ; Wilson Tang, W. H. ; Turnbaugh, Peter J. ; Walker, Alan W. ; Wilck, Nicola ; Xu, Jiaojiao ; Yang, Tao ; Himmelfarb, Jonathan ; Redinbo, Matthew R. ; Wu, Gary D. ; Woodworth, Michael H. ; Ackerman, A. Lenore ; Winter, Sebastian ; Rinschen, Markus M. ; Hassan, Hatim A. ; Biruete, Annabel ; Anderson, Amanda H. ; Pluznick, Jennifer L.
• Description:
  More than 850 million individuals worldwide, accounting for 10-15% of the adult population, are estimated to have chronic kidney disease. Each of these individuals is host to tens of trillions of microorganisms that are collectively referred to as microbiota - a dynamic ecosystem that both influences host health and is itself influenced by changes in the host. Available evidence supports the existence of functional connections between resident microorganisms and kidney health that are altered in the context of specific kidney diseases, including acute kidney injury, chronic kidney disease and renal stone disease. Moreover, promising data from preclinical studies suggest that targeting of gut microbial pathways may provide new therapeutic opportunities for the treatment of kidney disease. This Roadmap describes current understanding of the mechanisms by which microorganisms regulate host organ function, the effects of kidney disease on the gut microbiome, and how these insights may contribute to the development of microbe-targeted therapeutics. We highlight key knowledge gaps that remain to be addressed and strategies for addressing these, outlining both the promise and the potential pitfalls of leveraging our understanding of the gut microbiota to better understand and treat kidney disease.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Gastrointestinal Microbiome
  • Kidney Diseases
  • Renal Insufficiency, Chronic
  • Acute Kidney Injury
  • Microbiota
• Source:
  Nature Reviews. Nephrology, 2025, v. 21, no. 10
• DOI:
  https://doi.org/10.1038/s41581-025-00988-5
• ISSN:
  1759-5061 ; 1759-507X
• Pubmed ID:
  40721656
• Pubmed Central ID:
  PMC12434838
• Document Type:
  Text
• Funding:
  U24 DK127726/DK/NIDDK NIH HHSUnited States/ ; U01 DK133090/DK/NIDDK NIH HHSUnited States/ ; K12 TR004415/TR/NCATS NIH HHSUnited States/ ; R21 AG081683/AG/NIA NIH HHSUnited States/ ; R01 DK107566/DK/NIDDK NIH HHSUnited States/ ; R01 AI118807/AI/NIAID NIH HHSUnited States/ ; R01 DK132278/DK/NIDDK NIH HHSUnited States/ ; K23 AI144036/AI/NIAID NIH HHSUnited States/ ; R01 DK130815/DK/NIDDK NIH HHSUnited States/ ; R01 HL172805/HL/NHLBI NIH HHSUnited States/ ; R01 CA255116/CA/NCI NIH HHSUnited States/ ; R01 DK139021/DK/NIDDK NIH HHSUnited States/ ; R01 DK114034/DK/NIDDK NIH HHSUnited States/ ; R01 AT011396/AT/NCCIH NIH HHSUnited States/ ; K23 DK138239/DK/NIDDK NIH HHSUnited States/ ; R01 DK137762/DK/NIDDK NIH HHSUnited States/ ; U24 DK137318/DK/NIDDK NIH HHSUnited States/ ; R01 DK125256/DK/NIDDK NIH HHSUnited States/ ; UM1 TR004771/TR/NCATS NIH HHSUnited States/ ; P01 HL147823/HL/NHLBI NIH HHSUnited States/ ; U24 DK060990/DK/NIDDK NIH HHSUnited States/ ; R01 DK133177/DK/NIDDK NIH HHSUnited States/ ; R01 DK138121/DK/NIDDK NIH HHSUnited States/ ; P30 DK050306/DK/NIDDK NIH HHSUnited States/ ; R01 DK121689/DK/NIDDK NIH HHSUnited States/ ; R01 HL103866/HL/NHLBI NIH HHSUnited States/ ; UM1 AI104681/AI/NIAID NIH HHSUnited States/ ; UH3 TR003288/TR/NCATS NIH HHSUnited States/ ; R35 GM142873/GM/NIGMS NIH HHSUnited States/ ; U54 CK000601/CK/NCEZID CDC HHSUnited States/ ; U01 DK099924/DK/NIDDK NIH HHSUnited States/ ; R21 AI171537/AI/NIAID NIH HHSUnited States/ ; U54 DK137331/DK/NIDDK NIH HHSUnited States/ ; RM1 GM135102/GM/NIGMS NIH HHSUnited States/ ; R01 DK138912/DK/NIDDK NIH HHSUnited States/ ; R01 HL171401/HL/NHLBI NIH HHSUnited States/ ; R21 AG079357/AG/NIA NIH HHSUnited States/ ; R01 HL122593/HL/NHLBI NIH HHSUnited States/ ; U01 DK099914/DK/NIDDK NIH HHSUnited States/ ; R35 GM152079/GM/NIGMS NIH HHSUnited States/ ; R01 DK123342/DK/NIDDK NIH HHSUnited States/ ; K08 DK118176/DK/NIDDK NIH HHSUnited States/ ; U24 DK114886/DK/NIDDK NIH HHSUnited States/ ; R21 AI166263/AI/NIAID NIH HHSUnited States/ ; R61 AT013008/AT/NCCIH NIH HHSUnited States/ ; U2C TR004867/TR/NCATS NIH HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  702-716 (37 pdf pages)
• Volume:
  21
• Issue:
  10
• Download URL:
  https://stacks.cdc.gov/view/cdc/261223/cdc_261223_DS1.pdf
• File Type:
  [PDF - 504.70 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:8dc74f49d022f38b4386d171fd84565570e6ec5d84ec5765f547272e4c11193db413c2abfcedd8bf53419593f22b6f3f72234dd8045d8cc72df708f36fa580cd