Microbiome Therapeutics For Clostridioides Difficile Infection.

Details

• Alternative Title:
  Infectious Disease Clinics of North America, December 2025: Microbiome Therapeutics For Clostridioides Difficile Infection.
• Journal Article:
  Infectious Disease Clinics of North America
• Personal Author:
  Lucky, Christine W. ; Kelly, Brendan J. ; Kwon, Jennie H. ; Woodworth, Michael H. ; Medernach, Rachel L.
• Description:
  Microbiota-based therapies are used increasingly for the treatment and prevention of Clostridioides difficile infection (CDI), particularly in cases of recurrent CDI (rCDI). This review discusses the different types of microbiota-based therapies, including fecal microbiota transplant, fecal microbiota products, and live biotherapeutic products. The authors present efficacy data regarding clinical use in rCDI and highlight the unique aspects of each product.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Clostridium Infections
  • Fecal Microbiota Transplantation
  • Clostridioides difficile
  • Gastrointestinal Microbiome
  • Probiotics
• Keywords:
  • Clostridioides difficile
  • infection
  • Fecal microbiota transplant
  • Fecal microbiota products
  • Live biotherapeutic products
  • Recurrent
  • C difficile
  • Microbiome
• Source:
  Infectious Disease Clinics of North America, December 2025
• DOI:
  https://doi.org/10.1016/j.idc.2025.07.007
• ISSN:
  0891-5520 ; 1557-9824
• Pubmed ID:
  40796472
• Pubmed Central ID:
  PMC12435572
• Document Type:
  Text
• Funding:
  K23 AI144036/AI/NIAID NIH HHSUnited States/ ; U54 CK000601/CK/NCEZID CDC HHSUnited States/ ; U54 CK000607/CK/NCEZID CDC HHSUnited States/ ; U54 CK000609/CK/NCEZID CDC HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  S0891-5520(25)00070 (23 pdf pages)
• Download URL:
  https://stacks.cdc.gov/view/cdc/261181/cdc_261181_DS1.pdf
• File Type:
  [PDF - 502.08 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:a65cce0fcc88ae9505e5fc8ad9f86a30af88f0bd98610ecc9a57c3753f91bc477a4bb17fd032b57f8c65bf0304b2927c26a8562c68cd3e1072b26b83ce78a658