epidemiology and Risk Factors For Mortality in the United States, 2000-2022.

Details

• Alternative Title:
  Infectious Diseases (London, England), 2026, v. 58, no. 2: epidemiology and Risk Factors For Mortality in the United States, 2000-2022.
• Journal Article:
  Infectious Diseases (London, England)
• Personal Author:
  Hast, Marisa ; Baker-Austin, Craig ; Lake, Iain R. ; Paromita, Pritiza ; Cui, Zhaohui ; Jones, Natalia R. ; Posen, Paulette ; Hughes, Michael J.
• Description:
  is a foodborne and waterborne pathogen causing substantial morbidity and mortality; however, its epidemiology remains poorly understood. To inform prevention and control efforts, we characterized U.S.
  
  epidemiology and identified risk factors for mortality.
  
  For all culture-confirmed
  
  cases reported to the Cholera and Other
  
  Illness Surveillance (COVIS) system from 2000 to 2022, patient characteristics and medical outcomes were described by foodborne vs. non-foodborne transmission routes. Risk factors for mortality were identified using multivariate logistic regression.
  
  Two thousand nine hundred and eighty-nine
  
  cases were reported from 2000 to 2022, including 656 (22%) foodborne and 1,619 (54%) non-foodborne cases. Five-year case total increased 70% from 2000-2004 (
  
   = 487) to 2018-2022 (
  
   = 827). Most patients were male, older and White, with reported underlying health conditions; 2,493 (83%) patients were hospitalized and 692 (23%) died. Number of deaths (260 vs. 200) and fatality rate (40% vs. 12%) were higher among foodborne vs. non-foodborne cases. Mortality was associated with history of liver disease/alcoholism (odds ratio (OR) = 6.5,
  
   < 0.001), age 45-59 (OR = 11.3,
  
   = 0.001), foodborne transmission (OR = 1.3,
  
   = 0.006), and Black (OR = 1.8,
  
   = 0.03) or Asian (OR = 2.5,
  
   = 0.009) race. Antibiotic use was protective (OR = 0.33,
  
   = 0.001). Liver disease associated with diabetes had lower mortality than other forms of liver disease (interaction OR = 0.5,
  
   = 0.04).
  
  infections confer a substantial and increasing public health burden in the United States. Non-foodborne transmission caused 2.5 times more cases, and foodborne transmission caused 30% more deaths and had >3 times higher fatality rate. Identifying risk factors for mortality can inform public health and medical interventions.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Vibrio Infections
  • Male
  • Female
  • Vibrio vulnificus
  • Risk Factors
  • Middle Aged
  • Adult
  • Aged
  • Young Adult
  More +
• Keywords:
  • Vibrio vulnificus
  • vibriosis
  • epidemiology
  • foodborne illness
  • wound exposure
• Source:
  Infectious Diseases (London, England), 2026, v. 58, no. 2
• DOI:
  https://doi.org/10.1080/23744235.2025.2559883
• ISSN:
  2374-4235 ; 2374-4243
• Pubmed ID:
  40982344
• Pubmed Central ID:
  PMC12505355
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  209-220 (19 pdf pages)
• Volume:
  58
• Issue:
  2
• Download URL:
  https://stacks.cdc.gov/view/cdc/261043/cdc_261043_DS1.pdf
• File Type:
  [PDF - 1.63 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:11b296abb7b5bb027a27873d91e85c02d32412d0651e8be23ad1b12bef0ef71e1d6461bc8550e092db93eca765ace403ebdf631fafaf3a5873f42ce5f5273dec